Phenolics

Name	Plant	Family	Medicinal Plant	Compound	Category	Function	Reference
Delila	Antirrhinum majus	Plantaginaceae Juss.	Yes	Red anthocyanin	Flavonoid	Activator	Goodrich J, Carpenter R, Coen ES. A common gene regulates pigmentation pattern in diverse plant species. Cell. 1992;68(5):955-964. doi:10.1016/0092-8674(92)90038-e
CmMYB6	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Activator	Liu J, Osbourn A, Ma P. MYB transcription factors as regulators of phenylpropanoid metabolism in plants. Mol Plant. 2015;8(5):689-708. doi: 10.1016/j.molp.2015.03.012 Hong Y, Li M, Dai S. Ectopic Expression of Multiple Chrysanthemum (Chrysanthemum × morifolium) R2R3-MYB Transcription Factor Genes Regulates Anthocyanin Accumulation in Tobacco. Genes (Basel). 2019;10(10):777. doi:10.3390/genes10100777
CmMYB7	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Activator	Hong Y, Li M, Dai S. Ectopic Expression of Multiple Chrysanthemum (Chrysanthemum × morifolium) R2R3-MYB Transcription Factor Genes Regulates Anthocyanin Accumulation in Tobacco. Genes (Basel). 2019;10(10):777. doi:10.3390/genes10100777
CmMYB9a	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Activator	Wang Y, Zhou LJ, Wang Y, et al. CmMYB9a activates floral coloration by positively regulating anthocyanin biosynthesis in chrysanthemum. Plant Mol Biol. 2022;108(1-2):51-63. doi:10.1007/s11103-021-01206-z
CmMYB21	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Repressor	Wang Y, Zhou LJ , Wang Y ,et al.An R2R3-MYB transcription factor CmMYB21 represses anthocyanin biosynthesis in color fading petals of chrysanthemum[J]. Scientia Horticulturae. 2022;293:110674-. doi:10.1016/j.scienta.2021.110674.
CmMYB7	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Repressor	Xiang L, Liu X, Li H, et al. CmMYB#7, an R3 MYB transcription factor, acts as a negative regulator of anthocyanin biosynthesis in chrysanthemum. J Exp Bot. 2019;70(12):3111-3123. doi:10.1093/jxb/erz121
CmMYB4	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Repressor	Hong Y, Li M, Dai S. Ectopic Expression of Multiple Chrysanthemum (Chrysanthemum × morifolium) R2R3-MYB Transcription Factor Genes Regulates Anthocyanin Accumulation in Tobacco. Genes (Basel). 2019;10(10):777. doi:10.3390/genes10100777
CmMYB5	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Repressor	Hong Y, Li M, Dai S. Ectopic Expression of Multiple Chrysanthemum (Chrysanthemum × morifolium) R2R3-MYB Transcription Factor Genes Regulates Anthocyanin Accumulation in Tobacco. Genes (Basel). 2019;10(10):777. doi:10.3390/genes10100777
CmMYB1	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Flavonoid	Flavonoid	Repressor	Zhu L, Shan H, Chen S, et al. The Heterologous Expression of the Chrysanthemum R2R3-MYB Transcription Factor CmMYB1 Alters Lignin Composition and Represses Flavonoid Synthesis in Arabidopsis thaliana. PLoS One. 2013;8(6):e65680. doi:10.1371/journal.pone.0065680
CmMYB8	Chrysanthemum morifolium	Asteraceae Bercht. & J. Presl	Yes	Flavonoid	Flavonoid	Repressor	Zhu L, Guan Y, Zhang Z, et al. CmMYB8 encodes an R2R3 MYB transcription factor which represses lignin and flavonoid synthesis in chrysanthemum. Plant Physiol Biochem. 2020;149:217-224. doi:10.1016/j.plaphy.2020.02.010
DvIVS	Dahlia variabilis	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Activator	Ohno S, Hosokawa M, Hoshino A, et al. A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). J Exp Bot. 2011;62(14):5105-5116. doi:10.1093/jxb/err216
EsAN2	Epimedium sagittatum	Berberidaceae	Yes	Anthocyanin	Flavonoid	Activator	Huang W, Khaldun AB, Lv H, Du L, Zhang C, Wang Y. Isolation and functional characterization of a R2R3-MYB regulator of the anthocyanin biosynthetic pathway from Epimedium sagittatum. Plant Cell Rep. 2016;35(4):883-894. doi:10.1007/s00299-015-1929-z
EsMYBA1	Epimedium sagittatum	Berberidaceae	Yes	Anthocyanin	Flavonoid	Activator	Huang W, Sun W, Lv H, et al. A R2R3-MYB transcription factor from Epimedium sagittatum regulates the flavonoid biosynthetic pathway. PLoS One. 2013;8(8):e70778. doi:10.1371/journal.pone.0070778
EsMYB9	Epimedium sagittatum	Berberidaceae	Yes	Flavonoid	Flavonoid	Activator	Huang W, Lv H, Wang Y. Functional Characterization of a Novel R2R3-MYB Transcription Factor Modulating the Flavonoid Biosynthetic Pathway from Epimedium sagittatum. Front Plant Sci. 2017;8:1274. doi:10.3389/fpls.2017.01274
EsMYBF1	Epimedium sagittatum	Berberidaceae	Yes	Flavonol	Flavonoid	Activator	Huang W, Khaldun AB, Chen J, et al. A R2R3-MYB Transcription Factor Regulates the Flavonol Biosynthetic Pathway in a Traditional Chinese Medicinal Plant, Epimedium sagittatum. Front Plant Sci. 2016;7:1089. doi:10.3389/fpls.2016.01089
EbbHLH80	Erigeron breviscapus	Asteraceae Bercht. & J. Presl	Yes	Flavonoid	Flavonoid	Activator	Gao Q, Song W, Li X, et al. Genome-wide identification of bHLH transcription factors: Discovery of a candidate regulator related to flavonoid biosynthesis in Erigeron breviscapus. Front Plant Sci. 2022;13:977649. doi:10.3389/fpls.2022.977649
EbMYBP1	Erigeron breviscapus	Asteraceae Bercht. & J. Presl	Yes	Flavonoid	Flavonoid	Activator	Zhao Y, Zhang G, Tang Q, et al. EbMYBP1, a R2R3-MYB transcription factor, promotes flavonoid biosynthesis in Erigeron breviscapus. Front Plant Sci. 2022;13:946827. doi:10.3389/fpls.2022.946827
GtbHLH1	Eustoma Russellianum	Gentianaceae	Yes	Anthocyanin	Flavonoid	Activator	Nakatsuka T, Haruta KS, Pitaksutheepong C, et al. Identification and characterization of R2R3-MYB and bHLH transcription factors regulating anthocyanin biosynthesis in gentian flowers. Plant Cell Physiol. 2008;49(12):1818-1829. doi:10.1093/pcp/pcn163
FtMYB18	Fagopyrum tataricum	Polygonaceae	Yes	Anthocyanin	Flavonoid	Repressor	Dong Q, Zhao H, Huang Y, et al. FtMYB18 acts as a negative regulator of anthocyanin/proanthocyanidin biosynthesis in Tartary buckwheat. Plant Mol Biol. 2020;104(3):309-325. doi:10.1007/s11103-020-01044-5
FtMYB31	Fagopyrum tataricum	Polygonaceae	Yes	Flavonoid	Flavonoid	Activator	Sun Z, Linghu B, Hou S, Liu R, Wang L, Hao Y, Han Y, Zhou M, Liu L, Li H (2019) Tartary Buckwheat FtMYB31 Gene Encoding an R2R3-MYB Transcription Factor Enhances Flavonoid Accumulation in Tobacco. J Plant Growth Regul 39 (2):564-574. doi:10.1007/s00344-019-10000-7
FtMYB45	Fagopyrum tataricum	Polygonaceae	Yes	Flavonoid	Flavonoid	Repressor	Wen D, Wu L, Wang M, Yang W, Wang X, Ma W, Sun W, Chen S, Xiang L, Shi Y. CRISPR/Cas9-Mediated Targeted Mutagenesis of FtMYB45 Promotes Flavonoid Biosynthesis in Tartary Buckwheat (Fagopyrum tataricum). Front Plant Sci. 2022;13:879390. doi:10.3389/fpls.2022.879390
FtMYB6	Fagopyrum tataricum	Polygonaceae	Yes	Flavonol	Flavonoid	Activator	Yao P, Huang Y, Dong Q, Wan M, Wang A, Chen Y, Li C, Wu Q, Chen H, Zhao H. FtMYB6, a Light-Induced SG7 R2R3-MYB Transcription Factor, Promotes Flavonol Biosynthesis in Tartary Buckwheat (Fagopyrum tataricum). J Agric Food Chem. 2020;68 (47):13685-13696. doi:10.1021/acs.jafc.0c03037
FtMYB1	Fagopyrum tataricum	Polygonaceae	Yes	Proanthocyanidin	Flavonoid	Activator	Bai YC, Li CL, Zhang JW, et al. Characterization of two tartary buckwheat R2R3-MYB transcription factors and their regulation of proanthocyanidin biosynthesis. Physiol Plant. 2014;152(3):431-440. doi:10.1111/ppl.12199
FtMYB2	Fagopyrum tataricum	Polygonaceae	Yes	Proanthocyanidin	Flavonoid	Activator	Bai YC, Li CL, Zhang JW, et al. Characterization of two tartary buckwheat R2R3-MYB transcription factors and their regulation of proanthocyanidin biosynthesis. Physiol Plant. 2014;152(3):431-440. doi:10.1111/ppl.12199
FtMYB18	Fagopyrum tataricum	Polygonaceae	Yes	Proanthocyanidin	Flavonoid	Repressor	Dong Q, Zhao H, Huang Y, et al. FtMYB18 acts as a negative regulator of anthocyanin/proanthocyanidin biosynthesis in Tartary buckwheat. Plant Mol Biol. 2020;104(3):309-325. doi:10.1007/s11103-020-01044-5
FtMYB116	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Activator	Zhang D, Jiang C, Huang C, et al. The light-induced transcription factor FtMYB116 promotes accumulation of rutin in Fagopyrum tataricum. Plant Cell Environ. 2019;42(4):1340-1351. doi:10.1111/pce.13470
FtMYB11	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Repressor	Zhou M, Sun Z, Ding M, et al. FtSAD2 and FtJAZ1 regulate activity of the FtMYB11 transcription repressor of the phenylpropanoid pathway in Fagopyrum tataricum. New Phytol. 2017;216(3):814-828. doi:10.1111/nph.14692
FtMYB13	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Repressor	Zhang K, Logacheva MD, Meng Y, et al. Jasmonate-responsive MYB factors spatially repress rutin biosynthesis in Fagopyrum tataricum. J Exp Bot. 2018;69(8):1955-1966. doi:10.1093/jxb/ery032
FtMYB14	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Repressor	Zhang K, Logacheva MD, Meng Y, et al. Jasmonate-responsive MYB factors spatially repress rutin biosynthesis in Fagopyrum tataricum. J Exp Bot. 2018;69(8):1955-1966. doi:10.1093/jxb/ery032
FtMYB15	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Repressor	Zhang K, Logacheva MD, Meng Y, et al. Jasmonate-responsive MYB factors spatially repress rutin biosynthesis in Fagopyrum tataricum. J Exp Bot. 2018;69(8):1955-1966. doi:10.1093/jxb/ery032
FtMYB16	Fagopyrum tataricum	Polygonaceae	Yes	Rutin	Flavonoid	Repressor	Zhang K, Logacheva MD, Meng Y, et al. Jasmonate-responsive MYB factors spatially repress rutin biosynthesis in Fagopyrum tataricum. J Exp Bot. 2018;69(8):1955-1966. doi:10.1093/jxb/ery032
FtHY5-1	Fagopyrum tataricum	Polygonaceae	Yes	Flavonoid	Flavonoid	Activator	Wang Z. Study on Fagopyrum Tataricum HY5 Regulating the Biosynthesis of Flavonoids Under Blue Light Induction[D]. Heilongjiang University of Chinese Medicine. 2021. doi:10.27127/d.cnki.ghlzu.2021.000377.
FtHY5-1	Fagopyrum tataricum	Polygonaceae	Yes	Rutin, Quercetin	Flavonoid	Activator	Wang Z. Study on Fagopyrum Tataricum HY5 Regulating the Biosynthesis of Flavonoids Under Blue Light Induction[D]. Heilongjiang University of Chinese Medicine. 2021. doi:10.27127/d.cnki.ghlzu.2021.000377.
FtHY5-2	Fagopyrum tataricum	Polygonaceae	Yes	Flavonoid	Flavonoid	Activator	Wang Z. Study on Fagopyrum Tataricum HY5 Regulating the Biosynthesis of Flavonoids Under Blue Light Induction[D]. Heilongjiang University of Chinese Medicine. 2021. doi:10.27127/d.cnki.ghlzu.2021.000377.
FtHY5-2	Fagopyrum tataricum	Polygonaceae	Yes	Rutin, Quercetin	Flavonoid	Activator	Wang Z. Study on Fagopyrum Tataricum HY5 Regulating the Biosynthesis of Flavonoids Under Blue Light Induction[D]. Heilongjiang University of Chinese Medicine. 2021. doi:10.27127/d.cnki.ghlzu.2021.000377.
GhMYC1	Gerbera hybrida	Asteraceae Bercht. & J. Presl	Yes	Anthocyanin	Flavonoid	Activator	Elomaa P, Mehto M, Kotilainen M, Helariutta Y, Nevalainen L, Teeri TH. A bHLH transcription factor mediates organ, region and flower type specific signals on dihydroflavonol-4-reductase (dfr) gene expression in the inflorescence of Gerbera hybrida (Asteraceae). Plant J. 1998;16(1):93-99. doi:10.1046/j.1365-313x.1998.00273.x
GbbHLHs	Ginkgo biloba	Ginkgoaceae	Yes	Flavonoid	Flavonoid	Activator	Zhou X, Liao Y, Kim SU, et al. Genome-wide identification and characterization of bHLH family genes from Ginkgo biloba. Sci Rep. 2020;10(1):13723. doi:10.1038/s41598-020-69305-3
GbMYBFL	Ginkgo biloba	Ginkgoaceae	Yes	Flavonoid	Flavonoid	Activator	Zhang W, Xu F, Cheng S, Liao Y. Characterization and functional analysis of a MYB gene (GbMYBFL) related to flavonoid accumulation in Ginkgo biloba. Genes Genomics. 2018;40(1):49-61. doi:10.1007/s13258-017-0609-5
GbMYBF2	Ginkgo biloba	Ginkgoaceae	Yes	Flavonoid	Flavonoid	Repressor	Xu F, Ning Y, Zhang W, et al. An R2R3-MYB transcription factor as a negative regulator of the flavonoid biosynthesis pathway in Ginkgo biloba. Funct Integr Genomics. 2014;14(1):177-189. doi:10.1007/s10142-013-0352-1
GbMYBR1	Ginkgo biloba	Ginkgoaceae	Yes	Phenylpropanoid	Flavonoid	Repressor	Su X, Xia Y, Jiang W, Shen G, Pang Y. GbMYBR1 from Ginkgo biloba represses phenylpropanoid biosynthesis and trichome development in Arabidopsis. Planta. 2020;252(4):68. doi:10.1007/s00425-020-03476-1
GlMYB4	Glycyrrhiza uralensis	Fabaceae	Yes	Flavonoid	Flavonoid	Activator	Li Y, Chen X, Wang J, Zou G, Wang L, Li X. Two responses to MeJA induction of R2R3-MYB transcription factors regulate flavonoid accumulation in Glycyrrhiza uralensis Fisch. PLoS One. 2020;15(7):e0236565. doi:10.1371/journal.pone.0236565
GlMYB88	Glycyrrhiza uralensis	Fabaceae	Yes	Flavonoid	Flavonoid	Activator	Li Y, Chen X, Wang J, Zou G, Wang L, Li X. Two responses to MeJA induction of R2R3-MYB transcription factors regulate flavonoid accumulation in Glycyrrhiza uralensis Fisch. PLoS One. 2020;15(7):e0236565. doi:10.1371/journal.pone.0236565
GpMYB81	Gynostemma pentaphyllum	Cucurbitaceae	Yes	Flavonol	Flavonoid	Activator	Huang D, Ming R, Xu S, et al. Genome-Wide Identification of R2R3-MYB Transcription Factors: Discovery of a "Dual-Function" Regulator of Gypenoside and Flavonol Biosynthesis in Gynostemma pentaphyllum. Front Plant Sci. 2022;12:796248. doi:10.3389/fpls.2021.796248
IpIVS	Ipomoea purpurea	Convolvulaceae	Yes	Anthocyanin	Flavonoid	Activator	Park KI, Ishikawa N, Morita Y, Choi JD, Hoshino A, Iida S. A bHLH regulatory gene in the common morning glory, Ipomoea purpurea, controls anthocyanin biosynthesis in flowers, proanthocyanidin and phytomelanin pigmentation in seeds, and seed trichome formation. Plant J. 2007;49(4):641-654. doi:10.1111/j.1365-313X.2006.02988.x
ItIVS	Ipomoea tricolor	Convolvulaceae	Yes	Anthocyanin	Flavonoid	Activator	Park KI. A bHLH protein partially controls proanthocyanidin and phytomelanin pigmentation in the seed coats of morning glory Ipomoea tricolor. Hortic Environ Biotechnol. 2012;53:304-309.
Ii049	Isatis indigotica Fort.	Brassicaceae	Yes	Lignan	Flavonoid	Activator	Ma RF, Xiao Y, Lv ZY, Tan HX, Chen RB, Li Q, Chen JF, Wang Y, Yin J, Zhang L, Chen WS. AP2/ERF Transcription Factor, Ii049, Positively Regulates Lignan Biosynthesis in Isatis indigotica through Activating Salicylic Acid Signaling and Lignan/Lignin Pathway Genes. Front Plant Sci. 2017;8:1361. doi:10.3389/fpls.2017.01361
IiAP2/ERF063	Isatis indigotica Fort.	Brassicaceae	Yes	Lignan	Flavonoid	Activator	Xiao L, Ren JZ, Li Q, et al. Genome-wide analysis of AP2/ERF superfamily in Isatis indigotica. J Integr Med. 2023;21(1):77-88. doi:10.1016/j.joim.2022.09.003
Ii049	Isatis indigotica Fort.	Brassicaceae	Yes	Lignin	Flavonoid	Activator	Ma R, Xiao Y, Lv Z, et al. AP2/ERF Transcription Factor, Ii049, Positively Regulates Lignan Biosynthesis in Isatis indigotica through Activating Salicylic Acid Signaling and Lignan/Lignin Pathway Genes. Front Plant Sci. 2017;8:1361. doi:10.3389/fpls.2017.01361
LjaMYB12	Lonicera japonica	Caprifoliaceae	Yes	Flavonoid	Flavonoid	Activator	Qi X, Fang H, Chen Z, Liu Z, Yu X, Liang C. Ectopic Expression of a R2R3-MYB Transcription Factor Gene LjaMYB12 from Lonicera japonica Increases Flavonoid Accumulation in Arabidopsis thaliana. Int J Mol Sci. 2019;20(18):4494. doi:10.3390/ijms20184494
LmMYB15	Lonicera macranthoides	Caprifoliaceae	Yes	Chlorogenic acid	Flavonoid	Activator	Tang N, Cao Z, Yang C, et al. A R2R3-MYB transcriptional activator LmMYB15 regulates chlorogenic acid biosynthesis and phenylpropanoid metabolism in Lonicera macranthoides. Plant Sci. 2021;308:110924. doi:10.1016/j.plantsci.2021.110924
LmMYB15	Lonicera macranthoides	Caprifoliaceae	Yes	Phenylpropanoid	Flavonoid	Activator	Tang N, Cao Z, Yang C, et al. A R2R3-MYB transcriptional activator LmMYB15 regulates chlorogenic acid biosynthesis and phenylpropanoid metabolism in Lonicera macranthoides. Plant Sci. 2021;308:110924. doi:10.1016/j.plantsci.2021.110924
LbAN2	Lycium barbarum	Solanaceae Juss.	Yes	Anthocyanin	Flavonoid	Activator	Zong Y, Zhu X, Liu Z, et al. Functional MYB transcription factor encoding gene AN2 is associated with anthocyanin biosynthesis in Lycium ruthenicum Murray. BMC Plant Biol. 2019;19(1):169. doi:10.1186/s12870-019-1752-8
LrMYB1	Lycium ruthenicum	Solanaceae Juss.	Yes	Flavonoid	Flavonoid	Activator	Wang C, Dong Y, Zhu L, et al. Comparative transcriptome analysis of two contrasting wolfberry genotypes during fruit development and ripening and characterization of the LrMYB1 transcription factor that regulates flavonoid biosynthesis. BMC Genomics. 2020;21(1):295. doi:10.1186/s12864-020-6663-4
LrAN2	Lycium ruthenicum	Solanaceae Juss.	Yes	Anthocyanin	Flavonoid	Activator	Zong Y, Zhu X, Liu Z, et al. Functional MYB transcription factor encoding gene AN2 is associated with anthocyanin biosynthesis in Lycium ruthenicum Murray. BMC Plant Biol. 2019;19(1):169. doi:10.1186/s12870-019-1752-8; Ye G, Zheng Z, Zhou Y, et al. The MYB transcription factor LrAN2, from Lycium ruthenicum, led to enhanced accumulation of anthocyanins and modified profile of the total glycoalkaloids in potato[J]. Plant Cell Tissue and Organ Culture. 2021:1-10. doi:10.1007/s11240-021-02144-w.
PnWRKY22	Panax notoginseng	Araliaceae	Yes	Salicylic acid	Flavonoid	Activator	Ning K, Li M, Wei G, et al. Genomic and Transcriptomic Analysis Provide Insights Into Root Rot Resistance in Panax notoginseng. Front Plant Sci. 2021;12:775019. doi:10.3389/fpls.2021.775019
MYC-RP/GP	Perilla frutescens	Labiatae	Yes	Anthocyanin	Flavonoid	Activator	Gong ZZ, Yamagishi E, Yamazaki M, Saito K. A constitutively expressed Myc-like gene involved in anthocyanin biosynthesis from Perilla frutescens: molecular characterization, heterologous expression in transgenic plants and transactivation in yeast cells. Plant Mol Biol. 1999;41(1):33-44. doi:10.1023/a:1006237529040
PfMYB-P1	Perilla frutescens	Labiatae	Yes	Anthocyanin	Flavonoid	Activator	Gong ZZ, Yamagishi E, Yamazaki M, Saito K. A constitutively expressed Myc-like gene involved in anthocyanin biosynthesis from Perilla frutescens: molecular characterization, heterologous expression in transgenic plants and transactivation in yeast cells. Plant Mol Biol. 1999;41(1):33-44. doi:10.1023/a:1006237529040
PhAN1	Petunia hybrida	Solanaceae Juss.	Yes	Anthocyanin	Flavonoid	Activator	Quattrocchio F, Wing JF, Leppen H, Mol J, Koes RE. Regulatory genes controlling anthocyanin pigmentation are functionally conserved among plant species and have distinct sets of target genes. Plant Cell. 1993;5(11):1497-1512. doi:10.1105/tpc.5.11.1497
JAF13	Petunia hybrida	Solanaceae Juss.	Yes	Anthocyanin	Flavonoid	Activator	Quattrocchio F, Wing JF, van der Woude K, Mol JN, Koes R. Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes. Plant J. 1998;13(4):475-488. doi:10.1046/j.1365-313x.1998.00046.x
PlMYB1	Pueraria lobata	Fabaceae	Yes	Isoflavonoids	Flavonoid	Activator	Shen G, Wu R, Xia Y, Pang Y. Identification of Transcription Factor Genes and Functional Characterization of PlMYB1 From Pueraria lobata. Front Plant Sci. 2021;12:743518. doi:10.3389/fpls.2021.743518
SmbHLH74	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Flavonoid	Activator	Zhang X, Luo H, Xu Z, et al. Genome-wide characterisation and analysis of bHLH transcription factors related to tanshinone biosynthesis in Salvia miltiorrhiza. Sci Rep. 2015;5:11244. doi:10.1038/srep11244
SmbHLH92	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Flavonoid	Activator	Zhang X, Luo H, Xu Z, et al. Genome-wide characterisation and analysis of bHLH transcription factors related to tanshinone biosynthesis in Salvia miltiorrhiza. Sci Rep. 2015;5:11244. doi:10.1038/srep11244
SmMYC2	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acids	Flavonoid	Activator	Yang N, Zhou W, Su J, et al. Overexpression of SmMYC2 Increases the Production of Phenolic Acids in Salvia miltiorrhiza. Front Plant Sci. 2017;8:1804. doi:10.3389/fpls.2017.01804
SmbHLH37	Salvia miltiorrhiza	Labiatae	Yes	Salvianolic acid	Flavonoid	Repressor	Du T, Niu J, Su J, et al. SmbHLH37 Functions Antagonistically With SmMYC2 in Regulating Jasmonate-Mediated Biosynthesis of Phenolic Acids in Salvia miltiorrhiza. Front Plant Sci. 2018;9:1720. doi:10.3389/fpls.2018.01720
SmMYB1	Salvia miltiorrhiza	Labiatae	Yes	Anthocyanin	Flavonoid	Activator	Zhou W, Shi M, Deng C, et al. The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza. Hortic Res. 2021;8(1):10. doi:10.1038/s41438-020-00443-5
SmMYB1	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Activator	Zhou W, Shi M, Deng C, et al. The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza. Hortic Res. 2021;8(1):10. doi:10.1038/s41438-020-00443-5
SmPAP1	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Activator	Cloning, molecular characterization and functional analysis of a putative R2R3-MYB transcription factor of the phenolic acid biosynthetic pathway in S. miltiorrhiza Bge. f. alba[J]. Plant Cell Tissue & Organ Culture. 2016;124(1):151-168. doi:10.1007/s11240-015-0883-3.
SmMYB98	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Activator	Hao X, Pu Z, Cao G, et al. Tanshinone and salvianolic acid biosynthesis are regulated by SmMYB98 in Salvia miltiorrhiza hairy roots. J Adv Res. 2020;23:1-12. doi:10.1016/j.jare.2020.01.012
SmMYB4	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Repressor	Tian Q, Han L, Zhu X, et al. SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza. Metabolites. 2022;12(10):968. doi:10.3390/metabo12100968
SmMYB36	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Repressor	Ding K, Pei T, Bai Z, Jia Y, Ma P, Liang Z. SmMYB36, a Novel R2R3-MYB Transcription Factor, Enhances Tanshinone Accumulation and Decreases Phenolic Acid Content in Salvia miltiorrhiza Hairy Roots. Sci Rep. 2017;7(1):5104. doi:10.1038/s41598-017-04909-w
SmMYB2	Salvia miltiorrhiza	Labiatae	Yes	Salvianolic acid	Flavonoid	Activator	Deng C, Wang Y, Huang F, et al. SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza. J Integr Plant Biol. 2020;62(11):1688-1702. doi:10.1111/jipb.12943
SmMYB52	Salvia miltiorrhiza	Labiatae	Yes	Salvianolic acid B	Flavonoid	Activator	Yang R, Wang S, Zou H, et al. R2R3-MYB Transcription Factor SmMYB52 Positively Regulates Biosynthesis of Salvianolic Acid B and Inhibits Root Growth in Salvia miltiorrhiza. Int J Mol Sci. 2021;22(17):9538. doi:10.3390/ijms22179538
SmMYB111	Salvia miltiorrhiza	Labiatae	Yes	Salvianolic acid B	Flavonoid	Activator	Li S, Wu Y, Kuang J, et al. SmMYB111 Is a Key Factor to Phenolic Acid Biosynthesis and Interacts with Both SmTTG1 and SmbHLH51 in Salvia miltiorrhiza. J Agric Food Chem. 2018;66(30):8069-8078. doi:10.1021/acs.jafc.8b02548
SmWRKY34	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acids	Flavonoid	Repressor	Shi M, Zhu R, Zhang Y, et al. A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. Metab Eng. 2022;73:182-191. doi:10.1016/j.ymben.2022.08.002
SmbZIP1	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Activator	Deng CP, Shi M, Fu R, Zhang Y, Wang Q, Zhang Y, Wang Y, Ma XY, Kai GY. ABA-responsive transcription factor bZIP1 is involved in modulating biosynthesis of phenolic acids and tanshinones in Salvia miltiorrhiza. J Exp Bot. 2020;71(19):5948-5962.
SmbZIP2	Salvia miltiorrhiza	Labiatae	Yes	Phenolic acid	Flavonoid	Repressor	Shi M, Du ZY, Hua Q, Kai GY. CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis. Industrial Crops and Products. 2021;167:113560. doi:10.1016/j.indcrop.2021.113560
SmAREB1	Salvia miltiorrhiza	Labiatae	Yes	Salvianolic acid	Flavonoid	Activator	Jia YY, Bai ZQ, Pei TL, Ding K, Liang ZS, Gong YH. The Protein Kinase SmSnRK2.6 Positively Regulates Phenolic Acid Biosynthesis in Salvia miltiorrhiza by Interacting with SmAREB1. Front Plant Sci. 2017;8:1384. doi:10.3389/fpls.2017.01384
SbMYB12	Scutellaria baicalensis	Labiatae	Yes	Baicalin	Flavonoid	Activator	Wang WT, Hu SY, Yang J, Zhang CJ, Zhang T, Wang DH, Cao XY,Wang ZZ. A Novel R2R3-MYB Transcription Factor SbMYB12 Positively Regulates Baicalin Biosynthesis in Scutellaria baicalensis Georgi. Int J Mol Sci. 2022;23(24).
SbMYB8	Scutellaria baicalensis	Labiatae	Yes	Flavonoid	Flavonoid	Activator	Huang LQ, LiuYJ, Y J, et al. A Scutellaria baicalensis R2R3-MYB gene, SbMYB8, regulates flavonoid biosynthesis and improves drought stress tolerance in transgenic tobacco (vol 120, pg 961, 2015)[J]. Plant Cell Tissue & Organ Culture. 2015.
SbMYB2	Scutellaria baicalensis	Labiatae	Yes	Phenylpropanoid	Flavonoid	Activator	Qi L, Yang J, Yuan Y, Huang L, Chen P. Overexpression of two R2R3-MYB genes from Scutellaria baicalensis induces phenylpropanoid accumulation and enhances oxidative stress resistance in transgenic tobacco. Plant Physiol Biochem. 2015;94:235-243. doi:10.1016/j.plaphy.2015.06.007
SbMYB7	Scutellaria baicalensis	Labiatae	Yes	Phenylpropanoid	Flavonoid	Activator	Qi L, Yang J, Yuan Y, Huang L, Chen P. Overexpression of two R2R3-MYB genes from Scutellaria baicalensis induces phenylpropanoid accumulation and enhances oxidative stress resistance in transgenic tobacco. Plant Physiol Biochem. 2015;94:235-243. doi:10.1016/j.plaphy.2015.06.007
SbMYB12	Scutellaria baicalensis	Labiatae	Yes	Wogonoside	Flavonoid	Activator	Wang W, Hu S, Yang J, et al. A Novel R2R3-MYB Transcription Factor SbMYB12 Positively Regulates Baicalin Biosynthesis in Scutellaria baicalensis Georgi. Int J Mol Sci. 2022;23(24):15452. doi:10.3390/ijms232415452

Transcription factor (Phenolics)