Terpenoids

Name	Plant	Familia	Classified as a Medicinal Plant	Compound	Category	Function	Reference
TSARL1	Quinoa	Chenopodiaceae	Yes	Triterpene	Terpenoids	Activator	Jarvis D, Ho YS, Lightfoot D, Schmöckel S, Li B, Borm TA, Ohyanagi H, Mineta K, Michell C, Saber N, Kharbatia N, Rupper R, Sharp A, Dally N, Boughton B, Woo Y, Gao G, Schijlen E, Guo XJ, Momin A, Negrão S, Al-Babili S, Gehring C, Roessner U, Tester M. The genome of Chenopodium quinoa. Nature. 2017;542:307-312.
TSARL2	Quinoa	Chenopodiaceae	Yes	Triterpene	Terpenoids	Activator	Jarvis DE, Ho YS, Lightfoot DJ, et al. The genome of Chenopodium quinoa. Nature. 2017;542(7641):307-312. doi:10.1038/nature21370
PpbHLH4	Phalaenopsis bellina	Orchidaceae	Yes	Monoterpene	Terpenoids	Activator	Chuang YC, Hung YC, Tsai WC, Chen WH, Chen HH. PbbHLH4 regulates floral monoterpene biosynthesis in Phalaenopsis orchids. J Exp Bot. 2018;69(18):4363-4377. doi:10.1093/jxb/ery246
CrMYC1	Catharanthus roseus	Apocynaceae	Yes	Strictosidine	Terpenoids	Activator	Chatel G, Montiel G, Pré M, et al. CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter. J Exp Bot. 2003;54(392):2587-2588. doi:10.1093/jxb/erg275
CrMYC2	Catharanthus roseus	Apocynaceae	Yes	Terpenoid indole alkaloids	Terpenoids	Activator	Zhang H, Hedhili S, Montiel G, et al. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. Plant J. 2011;67(1):61-71. doi:10.1111/j.1365-313X.2011.04575.x
BIS1	Catharanthus roseus	Apocynaceae	Yes	Monoterpene indole alkaloid	Terpenoids	Activator	Van Moerkercke A, Steensma P, Schweizer F, et al. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Proc Natl Acad Sci U S A. 2015;112(26):8130-8135. doi:10.1073/pnas.1504951112
CrBPF1	Catharanthus roseus	Apocynaceae	Yes	Terpenoid indole alkaloid	Terpenoids	Repressor	Li CY, Leopold AL, Sander GW, Shanks JV, Zhao L, Gibson SI. CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes. Front Plant Sci. 2015;6:818. doi:10.3389/fpls.2015.00818
CrERF5	Catharanthus roseu	Apocynaceae	Yes	Anhydrovinblastine	Terpenoids	Activator	Pan Q, Wang C, Xiong Z, et al. CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus. Front Plant Sci. 2019;10:931. doi:10.3389/fpls.2019.00931
PnbHLH1	Panax notoginseng	Araliaceae	Yes	Triterpenoids	Terpenoids	Activator	Zhang X, Ge F, Deng B, et al. Molecular Cloning and Characterization of PnbHLH1 Transcription Factor in Panax notoginseng. Molecules. 2017;22(8):1268. doi:10.3390/molecules22081268
PgMYB2	Panax ginseng	Araliaceae	Yes	Ginsenoside	Terpenoids	Activator	Liu T, Luo T, Guo X, et al. PgMYB2, a MeJA-Responsive Transcription Factor, Positively Regulates the Dammarenediol Synthase Gene Expression in Panax Ginseng. Int J Mol Sci. 2019;20(9):2219. doi:10.3390/ijms20092219
PnMYB2	Panax notoginseng	Araliaceae	Yes	Ginsenoside	Terpenoids	Unclear	Xia P, Hu W, Zheng Y, Wang Y, Yan K, Liang Z. Structural and interactions analysis of a transcription factor PnMYB2 in Panax notoginseng. J Plant Physiol. 2022;275:153756. doi:10.1016/j.jplph.2022.153756
PgWRKY4X	Panax ginseng	Araliaceae	Yes	Ginsenosides	Terpenoids	Activator	Yao L, Wang J, Sun JC, He JP, Paek KY, Park SY, Huang LQ, Gao WY. A WRKY transcription factor, PgWRKY4X, positively regulates ginsenoside biosynthesis by activating squalene epoxidase transcription in Panax ginseng. Industrial Crops and Products. 2020;154:112671. doi:10.1016/j.indcrop.2020.112671
PnWRKY9	Panax notoginseng	Araliaceae	Yes	Notoginsenoside	Terpenoids	Activator	Zheng L, Qiu B, Su L, et al. Panax notoginseng WRKY Transcription Factor 9 Is a Positive Regulator in Responding to Root Rot Pathogen Fusarium solani. Front Plant Sci. 2022;13:930644. doi:10.3389/fpls.2022.930644
PnERF1	Panax notoginseng	Araliaceae	Yes	Ginsenoside (Rg3, Rh1, Rd, Rg1, F1 and Re)	Terpenoids	Activator	Deng B, Huang ZJ, Ge F, Liu DQ, Lu RJ, Chen CY. An AP2/ERF Family Transcription Factor PnERF1 Raised the Biosynthesis of Saponins in Panax notoginseng. J Plant Growth Regul. 2017;36:691-701. doi:10.1007/s00344-017-9672-z
AabHLH1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Ji Y, Xiao J, Shen Y, et al. Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua. Plant Cell Physiol. 2014;55(9):1592-1604. doi:10.1093/pcp/pcu090
AaMYB1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Matías-Hernández L, Jiang W, Yang K, Tang K, Brodelius PE, Pelaz S. AaMYB1 and its orthologue AtMYB61 affect terpene metabolism and trichome development in Artemisia annua and Arabidopsis thaliana. Plant J. 2017;90(3):520-534. doi:10.1111/tpj.13509
AaMYB108	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Liu H, Li L, Fu X, et al. AaMYB108 is the core factor integrating light and jasmonic acid signaling to regulate artemisinin biosynthesis in Artemisia annua. New Phytol. 2023;237(6):2224-2237. doi:10.1111/nph.18702
AaMYB15	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Repressor	Wu Z, Li L, Liu H, et al. AaMYB15, an R2R3-MYB TF in Artemisia annua, acts as a negative regulator of artemisinin biosynthesis. Plant Sci. 2021;308:110920. doi:10.1016/j.plantsci.
AaTLR1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Repressor	Lv Z, Li J, Qiu S, et al. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. J Integr Plant Biol. 2022;64(6):1212-1228. doi:10.1111/jipb.13258
AaTLR2	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Repressor	Lv Z, Li J, Qiu S, et al. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. J Integr Plant Biol. 2022;64(6):1212-1228. doi:10.1111/jipb.13258
AaWRKY1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Chen M, Yan T, Shen Q, et al. GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua. New Phytol. 2017;214(1):304-316. doi:10.1111/nph.14373
AaWRKY9	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Fu X, Peng B, Hassani D, et al. AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua. New Phytol. 2021;231(5):1858-1874. doi:10.1111/nph.17453
AaWRKY4	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Huang, H., Xing, S., Tang, K. et al. AaWRKY4 upregulates artemisinin content through boosting the expressions of key enzymes in artemisinin biosynthetic pathway. Plant Cell Tiss Organ Cult. 2021;146, 97–105. doi:10.1007/s11240-021-02049-8
AaGSW2	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Xie L, Yan T, Li L, et al. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021;72(5):1691-1701. doi:10.1093/jxb/eraa523
AaGSW1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Xie L, Yan T, Li L, et al. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021;72(5):1691-1701. doi:10.1093/jxb/eraa523
AaGSW1	Artemisia annua	Asteraceae	Yes	Dihydroartemisinic acid	Terpenoids	Activator	Xie L, Yan T, Li L, et al. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021;72(5):1691-1701. doi:10.1093/jxb/eraa523
AaWRKY1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Chen M, Yan T, Shen Q, et al. GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua. New Phytol. 2017;214(1):304-316. doi:10.1111/nph.14373
AaWRKY9	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Fu X, Peng B, Hassani D, et al. AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua. New Phytol. 2021;231(5):1858-1874. doi:10.1111/nph.17453
AaWRKY4	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Huang HZ, Xing SH, Tang KX, Jiang WM. AaWRKY4 upregulates artemisinin content through boosting the expressions of key enzymes in artemisinin biosynthetic pathway. Plant Cell Tiss Organ Cult. 2021;146:97-105. doi:10.1007/s11240-021-02049-8
AaGSW2	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Xie L, Yan T, Li L, et al. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021;72(5):1691-1701. doi:10.1093/jxb/eraa523
AabZIP1	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Shu G, Tang Y, Yuan M, et al. Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua. Acta Pharm Sin B. 2022;12(3):1500-1513. doi:10.1016/j.apsb.2021.09.026
AabZIP9	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Shen Q, Huang H, Zhao Y, et al. The Transcription Factor Aabzip9 Positively Regulates the Biosynthesis of Artemisinin in Artemisia annua. Front Plant Sci. 2019;10:1294. doi:10.3389/fpls.2019.01294
AaABF3	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Zhong Y, Li L, Hao X, et al. AaABF3, an Abscisic Acid-Responsive Transcription Factor, Positively Regulates Artemisinin Biosynthesis in Artemisia annua. Front Plant Sci. 2018;9:1777. doi:10.3389/fpls.2018.01777
AaHY5	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Hao X, Zhong Y, Nï Tzmann HW, et al. Light-Induced Artemisinin Biosynthesis Is Regulated by the bZIP Transcription Factor AaHY5 in Artemisia annua. Plant Cell Physiol. 2019;60(8):1747-1760. doi:10.1093/pcp/pcz084
AaTGA6	Artemisia annua	Asteraceae	Yes	Artemisinin	Terpenoids	Activator	Lv Z, Guo Z, Zhang L, et al. Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua. J Exp Bot. 2019;70(15):3969-3979. doi:10.1093/jxb/erz166
TbbZIP1	Taraxacum brevicorniculatum	Asteraceae	Yes	Polyterpenoids	Terpenoids	Activator	Fricke J, Hillebrand A, Twyman RM, Prüfer D, Schulze Gronover C. Abscisic acid-dependent regulation of small rubber particle protein gene expression in Taraxacum brevicorniculatum is mediated by TbbZIP1. Plant Cell Physiol. 2013;54(4):448-464. doi:10.1093/pcp/pcs182
BpbHLH9	Betula platyphylla	Betulaceae	Yes	Triterpene	Terpenoids	Activator	Yin J, Li X, Zhan Y, et al. Cloning and expression of BpMYC4 and BpbHLH9 genes and the role of BpbHLH9 in triterpenoid synthesis in birch. BMC Plant Biol. 2017;17(1):214. doi:10.1186/s12870-017-1150-z
CsWRKY1	Cannabis sativa	Cannabaceae	Yes	Cannabinoids	Terpenoids	Repressor	Liu Y, Zhu P, Cai S, Haughn G, Page JE. Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L. Plant Mol Biol. 2021;106(1-2):49-65. doi:10.1007/s11103-021-01129-9
B1	Cucumis sativus	Cucurbitaceae	Yes	Cucurbitacin	Terpenoids	Activator	Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y, Yasukawa K, Bouwmeester HJ, Qi XQ, Zhang ZH, Lucas WJ, Huang SW. Biosynthesis, regulation, and domestication of bitterness in cucumber. Science. 2014;346(6213):1084-1088. doi:10.1126/science.1259215
Bt	Cucumis sativus	Cucurbitaceae	Yes	Cucurbitacin	Terpenoids	Activator	Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y, Yasukawa K, Bouwmeester HJ, Qi XQ, Zhang ZH, Lucas WJ, Huang SW. Biosynthesis, regulation, and domestication of bitterness in cucumber. Science. 2014;346(6213):1084-1088. doi:10.1126/science.1259215
GpMYB81	Gynostemma pentaphyllum	Cucurbitaceae	Yes	Gypenoside	Terpenoids	Activator	Huang D, Ming R, Xu S, et al. Genome-Wide Identification of R2R3-MYB Transcription Factors: Discovery of a "Dual-Function" Regulator of Gypenoside and Flavonol Biosynthesis in Gynostemma pentaphyllum. Front Plant Sci. 2022;12:796248. doi:10.3389/fpls.2021.796248
PatSWC4	Pogostemon cablin	Labiatae	Yes	Patchoulol	Terpenoids	Activator	Chen X, Li J, Liu Y, Wu D, Huang H, Zhan R, Chen W, Chen L. PatSWC4, a methyl jasmonate-responsive MYB (v-myb avian myeloblastosis viral oncogene homolog)-related transcription factor, positively regulates patchoulol biosynthesis in Pogostemon cablin. Ind Crop Prod. 2020; 154. doi:10.1016/j.indcrop.2020.112672
SmMYB9	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Zhang J, Zhou L, Zheng X, et al. Overexpression of SmMYB9b enhances tanshinone concentration in Salvia miltiorrhiza hairy roots. Plant Cell Rep. 2017;36(8):1297-1309. doi:10.1007/s00299-017-2154-8
SmMYB36	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Ding K, Pei T, Bai Z, Jia Y, Ma P, Liang Z. SmMYB36, a Novel R2R3-MYB Transcription Factor, Enhances Tanshinone Accumulation and Decreases Phenolic Acid Content in Salvia miltiorrhiza Hairy Roots. Sci Rep. 2017;7(1):5104. doi:10.1038/s41598-017-04909-w
SmMYB98	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Ding K, Pei T, Bai Z, Jia Y, Ma P, Liang Z. SmMYB36, a Novel R2R3-MYB Transcription Factor, Enhances Tanshinone Accumulation and Decreases Phenolic Acid Content in Salvia miltiorrhiza Hairy Roots. Sci Rep. 2017;7(1):5104. doi:10.1038/s41598-017-04909-w
SmMYB98b	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Liu L, Yang DF, Xing BC, Zhang CL, Lang ZS. SmMYB98b positive regulation to tanshinones in Salvia miltiorrhiza Bunge hairy roots. Plant Cell Tiss Organ Cult. 2020;140:459-467. doi:10.1007/s11240-019-01716-1
SmMYB4	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Repressor	Tian Q, Han L, Zhu X, et al. SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza. Metabolites. 2022;12(10):968. doi:10.3390/metabo12100968
PcWRKY44	Pogostemon cablin	Labiatae	Yes	Patchouli alcohol	Terpenoids	Activator	Wang X, Tang Y, Huang H, et al. Functional analysis of Pogostemon cablin farnesyl pyrophosphate synthase gene and its binding transcription factor PcWRKY44 in regulating biosynthesis of patchouli alcohol. Front Plant Sci. 2022;13:946629. doi:10.3389/fpls.2022.946629
SmWRKY61	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Chen Y, Wang Y, Guo J, et al. Integrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of SmWRKY61 on Tanshinone Biosynthesis in Salvia miltiorrhiza and Salvia castanea. Front Plant Sci. 2022;12:820582. doi:10.3389/fpls.2021.820582
SmWRKY1	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Cao W, Wang Y, Shi M, et al. Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza. Front Plant Sci. 2018;9:554. doi:10.3389/fpls.2018.00554
SmWRKY2	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Activator	Deng C, Hao X, Shi M, et al. Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. Plant Sci. 2019;284:1-8. doi:10.1016/j.plantsci.2019.03.007
SmWRKY34	Salvia miltiorrhiza	Labiatae	Yes	Tanshinones,	Terpenoids	Repressor	Shi M, Zhu R, Zhang Y, et al. A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. Metab Eng. 2022;73:182-191. doi:10.1016/j.ymben.2022.08.002
SmERF128	Salvia miltiorrhiza	Labiatae	Yes	Cryptotanshinone	Terpenoids	Activator	Zhang Y, Ji A, Xu Z, Luo H, Song J. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Mol Biol. 2019;100(1-2):83-93. doi:10.1007/s11103-019-00845-7
SmERF128	Salvia miltiorrhiza	Labiatae	Yes	Dihydrotanshinone I	Terpenoids	Activator	Zhang Y, Ji A, Xu Z, Luo H, Song J. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Mol Biol. 2019;100(1-2):83-93. doi:10.1007/s11103-019-00845-7
SmERF128	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone I	Terpenoids	Activator	Zhang Y, Ji A, Xu Z, Luo H, Song J. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Mol Biol. 2019;100(1-2):83-93. doi:10.1007/s11103-019-00845-7
SmERF128	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone IIA	Terpenoids	Activator	Zhang Y, Ji A, Xu Z, Luo H, Song J. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Mol Biol. 2019;100(1-2):83-93. doi:10.1007/s11103-019-00845-7
SmbZIP1	Salvia miltiorrhiza	Labiatae	Yes	Tanshinone	Terpenoids	Repressor	Deng C, Shi M, Fu R, et al. ABA-responsive transcription factor bZIP1 is involved in modulating biosynthesis of phenolic acids and tanshinones in Salvia miltiorrhiza. J Exp Bot. 2020;71(19):5948-5962. doi:10.1093/jxb/eraa295
bHLH3	Glycyrrhiza glabra Glycyrrhiza uralensis	Leguminosae	Yes	Triterpene saponins	Terpenoids	Activator	Tamura K, Yoshida K, Hiraoka Y, et al. The Basic Helix-Loop-Helix Transcription Factor GubHLH3 Positively Regulates Soyasaponin Biosynthetic Genes in Glycyrrhiza uralensis. Plant Cell Physiol. 2018;59(4):778-791. doi:10.1093/pcp/pcy046
TSAR1	Medicago truncatula	Leguminosae	Yes	Nonhemolytic saponin	Terpenoids	Activator	Mertens J, Pollier J, Vanden Bossche R, Lopez-Vidriero I, Franco-Zorrilla JM, Goossens A. The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. Plant Physiol. 2016;170(1):194-210. doi:10.1104/pp.15.01645
TSAR2	Medicago truncatula	Leguminosae	Yes	Hemolytic saponin	Terpenoids	Activator	Mertens J, Pollier J, Vanden Bossche R, Lopez-Vidriero I, Franco-Zorrilla JM, Goossens A. The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula. Plant Physiol. 2016;170(1):194-210. doi:10.1104/pp.15.01645
TSAR3	Medicago truncatula	Leguminosae	Yes	Hemolytic saponin	Terpenoids	Activator	Ribeiro B, Lacchini E, Bicalho KU, et al. A Seed-Specific Regulator of Triterpene Saponin Biosynthesis in Medicago truncatula. Plant Cell. 2020;32(6):2020-2042. doi:10.1105/tpc.19.00609
MtbZIP17	Medicago truncatula	Leguminosae	Yes	Triterpene saponins	Terpenoids	Activator	Ribeiro B, Erffelinck ML, Lacchini E, et al. Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula. Front Plant Sci. 2022;13:903793. doi:10.3389/fpls.2022.903793
MtbZIP60	Medicago truncatula	Leguminosae	Yes	Triterpene saponins	Terpenoids	Activator	Ribeiro B, Erffelinck ML, Lacchini E, et al. Interference between ER stress-related bZIP-type and jasmonate-inducible bHLH-type transcription factors in the regulation of triterpene saponin biosynthesis in Medicago truncatula. Front Plant Sci. 2022;13:903793. doi:10.3389/fpls.2022.903793
DoMYB26	Dendrobium officinale	Orchidaceae	Yes	Volatile terpenoids	Terpenoids	Activator	Lv Z, Li J, Qiu S, et al. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. J Integr Plant Biol. 2022;64(6):1212-1228. doi:10.1111/jipb.13258
DoMYB31	Dendrobium officinale	Orchidaceae	Yes	Volatile terpenoids	Terpenoids	Activator	Lv Z, Li J, Qiu S, et al. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. J Integr Plant Biol. 2022;64(6):1212-1228. doi:10.1111/jipb.13258
DoMYB29	Dendrobium officinale	Orchidaceae	Yes	Volatile terpenoids	Terpenoids	Repressor	Lv Z, Li J, Qiu S, et al. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. J Integr Plant Biol. 2022;64(6):1212-1228. doi:10.1111/jipb.13258
TcJAMYC1	Taxus cuspidata	Taxaceae	Yes	Taxol	Terpenoids	Repressor	Lenka SK, Nims NE, Vongpaseuth K, Boshar RA, Roberts SC, Walker EL. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcJAMYC2	Taxus cuspidata	Taxaceae	Yes	Taxol	Terpenoids	Repressor	Lenka SK, Nims NE, Vongpaseuth K, Boshar RA, Roberts SC, Walker EL. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcJAMYC4	Taxus cuspidata	Taxaceae	Yes	Taxol	Terpenoids	Repressor	Lenka SK, Nims NE, Vongpaseuth K, Boshar RA, Roberts SC, Walker EL. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcMYB29a	Taxus chinensis	Taxaceae	Yes	Paclitaxel	Terpenoids	Activator	Cao X, Xu L, Li L, Wan W, Jiang J. TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis. Front Plant Sci. 2022;13:804593. doi:10.3389/fpls.2022.804593
TmMYB3	Taxus media	Taxaceae	Yes	Paclitaxel	Terpenoids	Activator	Yu C, Luo X, Zhang C, et al. Tissue-specific study across the stem of Taxus media identifies a phloem-specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis. Plant J. 2020;103(1):95-110. doi:10.1111/tpj.14710
TmMYB39	Taxus media	Taxaceae	Yes	Paclitaxel	Terpenoids	Activator	Yu C, Huang J, Wu Q, et al. Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol in Taxus media. Hortic Res. 2022;9:uhac062. doi:10.1093/hr/uhac062
TcWRKY8	Taxus chinensis	Taxaceae	Yes	Taxol	Terpenoids	Activator	Zhang M, Chen Y, Nie L, et al. Transcriptome-wide identification and screening of WRKY factors involved in the regulation of taxol biosynthesis in Taxus chinensis. Sci Rep. 2018;8(1):5197. doi:10.1038/s41598-018-23558-1
BcbZIP134	Bupleurum chinense	Umbelliferae	Yes	Saikosaponin	Terpenoids	Repressor	Xu J, Wu SR, Xu YH, Ge ZY, Sui C,Wei JH. Overexpression of BcbZIP134 negatively regulates the biosynthesis of saikosaponins. Plant Cell Tiss Organ Cult. 2019;137:297-308.

Transcription factor (Terpenoids)