Phenolic pathway

Gene	Reference
PtHCT/PtHQT	Moglia A, Lanteri S, Comino C, et al. Dual catalytic activity of hydroxycinnamoyl-Coenzyme A quinate transferase from tomato allows it to moonlight in the synthesis of both mono-and dicaffeoylquinic acids[J]. Plant Physiology, 2014, 166(4): 1777-1787.
SlPMT	Moglia A, Lanteri S, Comino C, et al. Dual catalytic activity of hydroxycinnamoyl-Coenzyme A quinate transferase from tomato allows it to moonlight in the synthesis of both mono-and dicaffeoylquinic acids[J]. Plant Physiology, 2014, 166(4): 1777-1787.
AbCGT	Xie K, Zhang X, Sui S, et al. Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides[J]. Nature communications, 2020, 11(1): 1-12.
DcaCGT	Ren Z, Ji X, Jiao Z, et al. Functional analysis of a novel C-glycosyltransferase in the orchid Dendrobium catenatum[J]. Horticulture research, 2020, 7(1): 1-18.
MiCGTb	Chen D, Fan S, Chen R, et al. Probing and engineering key residues for bis-C-glycosylation and promiscuity of a C-glycosyltransferase[J]. ACS Catalysis, 2018, 8(6): 4917-4927.
SbCGTa	Wang Z L, Gao H M, Wang S, et al. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso) schaftosides in higher plants[J]. Proceedings of the National Academy of Sciences, 2020, 117(48): 30816-30823.
SbCGTb	Wang Z L, Gao H M, Wang S, et al. Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso) schaftosides in higher plants[J]. Proceedings of the National Academy of Sciences, 2020, 117(48): 30816-30823.
TcCGT1	He J B, Zhao P, Hu Z M, et al. Molecular and Structural Characterization of a Promiscuous C‐Glycosyltransferase from Trollius chinensis[J]. Angewandte Chemie International Edition, 2019, 58(33): 11513-11520.
PcCHS	Zhang Y, Zheng L, Zheng Y, Zhou C, Huang P, Xiao X, Zhao Y, Hao X, Hu Z, Chen Q, Li H, Wang X, Fukushima K, Wang G, Li C. (2019). Assembly and Annotation of a Draft Genome of the Medicinal Plant Polygonum cuspidatum. Frontiers in plant science, 10, 1274. https://doi.org/10.3389/fpls.2019.01274
SmCHS	Deng Y, Li C, Li H, Lu S. (2018). Identification and Characterization of Flavonoid Biosynthetic Enzyme Genes in Salvia miltiorrhiza (Lamiaceae). Molecules (Basel, Switzerland), 23(6), 1467. https://doi.org/10.3390/molecules23061467
AT1G11680	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
AtCYP705A1	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
AtCYP705A5	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
MaCYP71CD2, CsCYP71CD1	Hodgson H, De La Peña R, Stephenson M J, et al. Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production[J]. Proceedings of the National Academy of Sciences, 2019, 116(34): 17096-17104.
LjCYP71D353	Krokida A, Delis C, Geisler K, et al. A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis[J]. New Phytologist, 2013, 200(3): 675-690.
CYP714E19	Kim O T, Um Y, Jin M L, et al. A novel multifunctional C-23 oxidase, CYP714E19, is involved in asiaticoside biosynthesis[J]. Plant and Cell Physiology, 2018, 59(6): 1200-1213.
AtCYP716A	Yasumoto S, Fukushima E O, Seki H, et al. Novel triterpene oxidizing activity of Arabidopsis thaliana CYP716A subfamily enzymes[J]. Febs Letters, 2016, 590(4): 533-540.
AaCYP716A14v2	Moses T, Pollier J, Shen Q, et al. OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua[J]. The Plant Cell, 2015, 27(1): 286-301.
AtCYP716A1, AtCYP716A2	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
BfCYP716Y1	Moses T, Pollier J, Almagro L, et al. Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum[J]. Proceedings of the National Academy of Sciences, 2014, 111(4): 1634-1639.
BvCYP716A80, BvCYP716A81	Khakimov B, Kuzina V, Erthmann P Ø, et al. Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana[J]. The Plant Journal, 2015, 84(3): 478-490.
CaCYP714E19	Kim O T, Um Y, Jin M L, et al. A novel multifunctional C-23 oxidase, CYP714E19, is involved in asiaticoside biosynthesis[J]. Plant and Cell Physiology, 2018, 59(6): 1200-1213.
CqCYP716A78, CqCYP716A79	Fiallos-Jurado J, Pollier J, Moses T, et al. Saponin determination, expression analysis and functional characterization of saponin biosynthetic genes in Chenopodium quinoa leaves[J]. Plant Science, 2016, 250: 188-197.
EsCYP716A244	Jo H J, Han J Y, Hwang H S, et al. β-Amyrin synthase (EsBAS) and β-amyrin 28-oxidase (CYP716A244) in oleanane-type triterpene saponin biosynthesis in Eleutherococcus senticosus[J]. Phytochemistry, 2017, 135: 53-63.
GuCYP716A179	Tamura K, Seki H, Suzuki H, Kojoma M, Saito K, Muranaka T. CYP716A179 functions as a triterpene C-28 oxidase in tissue-cultured stolons of Glycyrrhiza uralensis. Plant Cell Rep. 2017;36(3):437-445.
LsCYP716A265, LsCYP716A266	Misra R C, Chanotiya C S, Mukhopadhyay P, et al. Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba[J]. New Phytologist, 2019, 222(1): 408-424.
MlCYP716A75	Moses T, Pollier J, Faizal A, et al. Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata[J]. Molecular plant, 2015, 8(1): 122-135.
MtCYP716A12	Carelli M, Biazzi E, Panara F, et al. Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins[J]. The plant cell, 2011, 23(8): 3070-3081.
PgCYP716A47	Han J Y, Kim H J, Kwon Y S, et al. The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng[J]. Plant and cell physiology, 2011, 52(12): 2062-2073.
PgCYP716A53v2	Han J Y, Hwang H S, Choi S W, et al. Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng[J]. Plant and cell physiology, 2012, 53(9): 1535-1545.
PgCYP716A141	Tamura K, Teranishi Y, Ueda S, et al. Cytochrome P450 monooxygenase CYP716A141 is a unique β-amyrin C-16β oxidase involved in triterpenoid saponin biosynthesis in Platycodon grandiflorus[J]. Plant and Cell Physiology, 2017, 58(5): 874-884.
SlCYP716A26, SlCYP716A44, SlCYP716A46	Yasumoto S, Seki H, Shimizu Y, et al. Functional characterization of CYP716 family P450 enzymes in triterpenoid biosynthesis in tomato[J]. Frontiers in plant science, 2017, 8: 21.
TkCYP716A263	Pütter K M, van Deenen N, Müller B, et al. The enzymes OSC1 and CYP716A263 produce a high variety of triterpenoids in the latex of Taraxacum koksaghyz[J]. Scientific reports, 2019, 9(1): 1-13.
BvCYP72A552	Liu Q, Khakimov B, Cárdenas P D, et al. The cytochrome P450 CYP72A552 is key to production of hederagenin‐based saponins that mediate plant defense against herbivores[J]. New Phytologist, 2019, 222(3): 1599-1609.
CrCYP72A224	Miettinen K, Dong L, Navrot N, et al. The seco-iridoid pathway from Catharanthus roseus[J]. Nature communications, 2014, 5(1): 1-12.
GuCYP72A154, GuCYP88D6	Seki H, Sawai S, Ohyama K, et al. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin[J]. The Plant Cell, 2011, 23(11): 4112-4123.
SlCYP734A7	Ohnishi T, Nomura T, Watanabe B, et al. Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism[J]. Phytochemistry, 2006, 67(17): 1895-1906.
OsCYP734A2, OsCYP734A4, OsCYP734A6	Sakamoto T, Kawabe A, Tokida‐Segawa A, et al. Rice CYP734As function as multisubstrate and multifunctional enzymes in brassinosteroid catabolism[J]. The Plant Journal, 2011, 67(1): 1-12.
CsCYP88L2, CsCYP81Q58, CsCYP89SA140	Shang Y, Ma Y, Zhou Y, et al. Biosynthesis, regulation, and domestication of bitterness in cucumber[J]. science, 2014, 346(6213): 1084-1088.
CsCYP87D20, CmCYP87D20, ClCYP87D20	Zhou Y, Ma Y, Zeng J, et al. Convergence and divergence of bitterness biosynthesis and regulation in Cucurbitaceae[J]. Nature plants, 2016, 2(12): 1-8.
CpCYP88P2, CpCYP88P3, CpCYP88P4	Hori K, Yamada Y, Purwanto R, et al. Mining of the uncharacterized cytochrome P450 genes involved in alkaloid biosynthesis in California poppy using a draft genome sequence[J]. Plant and Cell Physiology, 2018, 59(2): 222-233.
AtCYP85A3, AtCYP85A1	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
SICYP85A1, SICYP85A3	Nomura T, Kushiro T, Yokota T, et al. The last reaction producing brassinolide is catalyzed by cytochrome P-450s, CYP85A3 in tomato and CYP85A2 in Arabidopsis[J]. Journal of Biological Chemistry, 2005, 280(18): 17873-17879.
CsCYP87D20	Li Z, Zhang Z, Yan P, et al. RNA-Seq improves annotation of protein-coding genes in the cucumber genome[J]. BMC genomics, 2011, 12(1): 540.
MlCYP716A75	Moses T, Pollier J, Faizal A, et al. Unraveling the triterpenoid saponin biosynthesis of the African shrub Maesa lanceolata[J]. Molecular plant, 2015, 8(1): 122-135.
SgCYP87D18	Zhao H, Guo J, Tang Q, et al. Cloning and expression analysis of squalene epoxidase genes from Siraitia grosvenorii[J]. China journal of Chinese materia medica, 2018, 43(16): 3255-3262.
CsCYP88L2	Shang Y, Ma Y, Zhou Y, et al. Biosynthesis, regulation, and domestication of bitterness in cucumber[J]. science, 2014, 346(6213): 1084-1088.
GgCYP88D6, GgCYP93E6	Shirazi Z, Aalami A, Tohidfar M, et al. Metabolic engineering of glycyrrhizin pathway by over-expression of beta-amyrin 11-oxidase in transgenic roots of Glycyrrhiza glabra[J]. Molecular biotechnology, 2018, 60(6): 412-419.
McCYP88L7, McCYP88L8	Takase S, Kera K, Nagashima Y, et al. Allylic hydroxylation of triterpenoids by a plant cytochrome P450 triggers key chemical transformations that produce a variety of bitter compounds[J]. Journal of Biological Chemistry, 2019, 294(49): 18662-18673.
AtCYP90A1	Ohnishi T, Godza B, Watanabe B, et al. CYP90A1/CPD, a brassinosteroid biosynthetic cytochrome P450 of Arabidopsis, catalyzes C-3 oxidation[J]. Journal of Biological Chemistry, 2012, 287(37): 31551-31560.
AtCYP90C1, AtCYP90D1	Ohnishi T, Szatmari A M, Watanabe B, et al. C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis[J]. The Plant Cell, 2006, 18(11): 3275-3288.
LjCYP71D353	Hong Z, Ueguchi-Tanaka M, Umemura K, et al. A rice brassinosteroid-deficient mutant, ebisu dwarf (d2), is caused by a loss of function of a new member of cytochrome P450. Plant Cell. 2003;15(12):2900-2910.
PpCYP90G4, TfCYP90B50	Christ B, Xu C, Xu M, et al. Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants[J]. Nature communications, 2019, 10(1): 1-12.
GgCYP88D6	Shirazi Z, Aalami A, Tohidfar M, et al. Metabolic engineering of glycyrrhizin pathway by over-expression of beta-amyrin 11-oxidase in transgenic roots of Glycyrrhiza glabra[J]. Molecular biotechnology, 2018, 60(6): 412-419.
LjCYP93E1	Suzuki H, Fukushima E O, Shimizu Y, et al. Lotus japonicus triterpenoid profile and characterization of the CYP716A51 and LjCYP93E1 genes involved in their biosynthesis in planta[J]. Plant and Cell Physiology, 2019, 60(11): 2496-2509.
CbrCaOMT	Wang J, Pichersky E. Characterization of S-Adenosyl-l-methionine:(Iso) eugenolO-methyltransferase involved in floral scent production in Clarkia breweri[J]. Archives of biochemistry and biophysics, 1998, 349(1): 153-160.
Cch6OMT2	He S M, Liang Y L, Cong K, et al. Identification and characterization of genes involved in benzylisoquinoline alkaloid biosynthesis in Coptis species[J]. Frontiers in plant science, 2018, 9: 731.
Cja4′OMT	Morishige T, Tsujita T, Yamada Y, et al. Molecular characterization of the S-adenosyl-L-methionine: 3′-hydroxy-N-methylcoclaurine 4′-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica[J]. Journal of Biological Chemistry, 2000, 275(30): 23398-23405.
Cja6OMT	Morishige T, Tsujita T, Yamada Y, et al. Molecular characterization of the S-adenosyl-L-methionine: 3′-hydroxy-N-methylcoclaurine 4′-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica[J]. Journal of Biological Chemistry, 2000, 275(30): 23398-23405.
Ec4′ OMT	Inui T, Tamura K, Fujii N, et al. Overexpression of Coptis japonica norcoclaurine 6-O-methyltransferase overcomes the rate-limiting step in benzylisoquinoline alkaloid biosynthesis in cultured Eschscholzia californica[J]. Plant and cell physiology, 2007, 48(2): 252-262.
NnOMT1, NnOMT5	Menéndez-Perdomo I M, Facchini P J. Isolation and characterization of two O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus (Nelumbo nucifera)[J]. Journal of Biological Chemistry, 2020, 295(6): 1598-1612.
OpEOMT	Samanani N, Alcantara J, Bourgault R, et al. The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in Opium poppy[J]. The Plant Journal, 2006, 47(4): 547-563.
Op4′OMT	Samanani N, Alcantara J, Bourgault R, et al. The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in Opium poppy[J]. The Plant Journal, 2006, 47(4): 547-563.
OpPSOMT1	Ounaroon A, Frick S, Kutchan T M. Molecular Genetic Analysis of an O-Methyltransferase of the Opium Poppy (Papaver somniferum)[J]. Acta Hort. 675p, 2005.
Tf4′OMT	Samanani N, Yeung E C, Facchini P J. Cell type-specific protoberberine alkaloid accumulation in Thalictrum flavum[J]. Journal of plant physiology, 2002, 159(11): 1189-1196.
Tf6′OMT	Samanani N, Yeung E C, Facchini P J. Cell type-specific protoberberine alkaloid accumulation in Thalictrum flavum[J]. Journal of plant physiology, 2002, 159(11): 1189-1196.
TfSOMT	Samanani N, Yeung E C, Facchini P J. Cell type-specific protoberberine alkaloid accumulation in Thalictrum flavum[J]. Journal of plant physiology, 2002, 159(11): 1189-1196.
BvOMT	Getz H P, Klein M. Characteristics of sucrose transport and sucrose-induced H+ transport on the tonoplast of red beet (Beta vulgaris L.) storage tissue[J]. Plant Physiology, 1995, 107(2): 459-467.
ZeOMT	Ye Z H, Kneusel R E, Matern U, et al. An alternative methylation pathway in lignin biosynthesis in Zinnia[J]. The Plant Cell, 1994, 6(10): 1427-1439.
IaAS2	Wu Z, Xu H, Wang M, et al. Molecular docking and molecular dynamics studies on selective synthesis of α-amyrin and β-amyrin by oxidosqualene cyclases from llex asprella[J]. International journal of molecular sciences, 2019, 20(14): 3469.
AabAS	Kirby J, Romanini D W, Paradise E M, et al. Engineering triterpene production in Saccharomyces cerevisiae–β‐amyrin synthase from Artemisia annua[J]. The FEBS journal, 2008, 275(8): 1852-1859.
AaOSC2	Moses T, Pollier J, Shen Q, et al. OSC2 and CYP716A14v2 catalyze the biosynthesis of triterpenoids for the cuticle of aerial organs of Artemisia annua[J]. The Plant Cell, 2015, 27(1): 286-301.
AiOSC1	Pandreka A, Dandekar D S, Haldar S, et al. Triterpenoid profiling and functional characterization of the initial genes involved in isoprenoid biosynthesis in neem (Azadirachta indica)[J]. BMC plant biology, 2015, 15(1): 214.
KcCAS1	Basyuni M, Oku H, Tsujimoto E, et al. Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce[J]. Bioscience, biotechnology, and biochemistry, 2007, 71(7): 1788-1792.
AsOXA1	Cammareri M, Consiglio M F, Pecchia P, et al. Molecular characterization of β-amyrin synthase from Aster sedifolius L. and triterpenoid saponin analysis[J]. Plant Science, 2008, 175(3): 255-261.
AtSHS1	Sawai S, Uchiyama H, Mizuno S, et al. Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus[J]. FEBS letters, 2011, 585(7): 1031-1036.
AtCAS1	Lin X, Kaul S, Rounsley S, et al. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana[J]. Nature, 1999, 402(6763): 761-768.
AtLSS1	Theologis A, Ecker J R, Palm C J, et al. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 816-820.
AtMRN1	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
AtHAS1	Tabata S, Kaneko T, Nakamura Y, et al. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana[J]. Nature, 2000, 408(6814): 823-826.
BfOSC1, BfOSC2, BfOSC3	Srisawat P, Fukushima E O, Yasumoto S, et al. Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α‐amyrin‐producing activity[J]. New Phytologist, 2019, 224(1): 352-366.
BPW	Zhang H, Shibuya M, Yokota S, et al. Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants[J]. Biological and Pharmaceutical Bulletin, 2003, 26(5): 642-650.
BPX1	Zhang H, Shibuya M, Yokota S, et al. Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants[J]. Biological and Pharmaceutical Bulletin, 2003, 26(5): 642-650.
BPX2	Zhang H, Shibuya M, Yokota S, et al. Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants[J]. Biological and Pharmaceutical Bulletin, 2003, 26(5): 642-650.
BPY	Zhang H, Shibuya M, Yokota S, et al. Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants[J]. Biological and Pharmaceutical Bulletin, 2003, 26(5): 642-650.
CaDDS	Kim O T, Kim M Y, Huh S M, et al. Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban[J]. Plant cell reports, 2005, 24(5): 304-311.
CrAS	Huang L, Li J, Ye H, et al. Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus[J]. Planta, 2012, 236(5): 1571-1581.
CsOSC1	Kawano N, Ichinose K, Ebizuka Y. Molecular cloning and functional expression of cDNAs encoding oxidosqualene cyclases from Costus speciosus[J]. Biological and Pharmaceutical Bulletin, 2002, 25(4): 477-482.
ElLAS1, ElCAS1,ELBUT1	Forestier E, Romero-Segura C, Pateraki I, et al. Distinct triterpene synthases in the laticifers of Euphorbia lathyris[J]. Scientific reports, 2019, 9(1): 1-12.
EtAS	Kajikawa M, Yamato K T, Fukuzawa H, et al. Cloning and characterization of a cDNA encoding β-amyrin synthase from petroleum plant Euphorbia tirucalli L[J]. Phytochemistry, 2005, 66(15): 1759-1766.
EtLUS	Ma L T, Wang S Y, Tseng Y H, et al. Cloning and characterization of a 2, 3-oxidosqualene cyclase from Eleutherococcus trifoliatus[J]. Holzforschung, 2013, 67(4): 463-471.
GgLUS1	Hayashi H, Huang P, Takada S, et al. Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra[J]. Biological and Pharmaceutical Bulletin, 2004, 27(7): 1086-1092.
GsAS1	Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F. Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM. Biol Pharm Bull. 2009 May;32(5):818-24. doi: 10.1248/bpb.32.818. PMID: 19420748.
BS	Meesapyodsuk D, Balsevich J, Reed D W, et al. Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding β-amyrin synthase and a triterpene carboxylic acid glucosyltransferase[J]. Plant Physiology, 2007, 143(2): 959-969.
IaAS1, IaAS2	Zheng X, Luo X, Ye G, et al. Characterisation of two oxidosqualene cyclases responsible for triterpenoid biosynthesis in Ilex asprella[J]. International journal of molecular sciences, 2015, 16(2): 3564-3578.
RsCAS	Basyuni M, Oku H, Tsujimoto E, et al. Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce[J]. Bioscience, biotechnology, and biochemistry, 2007, 71(7): 1788-1792.
LcIMS1	Hayashi H, Huang P, Inoue K, et al. Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid[J]. European Journal of Biochemistry, 2001, 268(23): 6311-6317.
LcCAS1	Hayashi H, Hiraoka N, Ikeshiro Y, et al. Molecular cloning of a cDNA encoding cycloartenol synthase from Luffa cylindrica (accession no. AB033334)[R]. 1999.
LjOSC3	Sawai S, Shindo T, Sato S, et al. Functional and structural analysis of genes encoding oxidosqualene cyclases of Lotus japonicus[J]. Plant Science, 2006, 170(2): 247-257.
LjOSC5	Sawai S, Shindo T, Sato S, et al. Functional and structural analysis of genes encoding oxidosqualene cyclases of Lotus japonicus[J]. Plant Science, 2006, 170(2): 247-257.
LsOSC1, LsOSC2, LsOSC3, LsOSC4, LsOSC5	Misra R C, Chanotiya C S, Mukhopadhyay P, et al. Oxidosqualene cyclase and CYP716 enzymes contribute to triterpene structural diversity in the medicinal tree banaba[J]. New Phytologist, 2019, 222(1): 408-424.
MdOSC1, MdOSC3, MdOSC4, MdOSC5	Andre C M, Legay S, Deleruelle A, et al. Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids[J]. New Phytologist, 2016, 211(4): 1279-1294.
QsOSC1, QsOSC2, QsOSC3	Busta L, Serra O, Kim O T, et al. Oxidosqualene cyclases involved in the biosynthesis of triterpenoids in Quercus suber cork[J]. Scientific reports, 2020, 10(1): 1-12.
RcCAS	Guhling O, Hobl B, Yeats T, et al. Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis[J]. Archives of Biochemistry and Biophysics, 2006, 448(1-2): 60-72.
RcLUS	Guhling O, Hobl B, Yeats T, et al. Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis[J]. Archives of Biochemistry and Biophysics, 2006, 448(1-2): 60-72.
RsCAS	Basyuni M, Oku H, Tsujimoto E, et al. Cloning and functional expression of cycloartenol synthases from mangrove species Rhizophora stylosa Griff. and Kandelia candel (L.) Druce[J]. Bioscience, biotechnology, and biochemistry, 2007, 71(7): 1788-1792.
SaCAS	Bode H B, Zeggel B, Silakowski B, et al. Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2, 3 (S)‐oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca[J]. Molecular microbiology, 2003, 47(2): 471-481.
SgCBS	Li S L, Wang D, Liu Y, et al. Study of heterologous efficient synthesis of cucurbitadienol [J]. China journal of Chinese materia medica, 2017, 42(17): 3326-3331.
SlTTS1	Misra R C, Maiti P, Chanotiya C S, et al. Methyl jasmonate-elicited transcriptional responses and pentacyclic triterpene biosynthesis in sweet basil[J]. Plant Physiology, 2014, 164(2): 1028-1044.
SlTTS1-2	Wang Z, Guhling O, Yao R, et al. Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids[J]. Plant Physiology, 2011, 155(1): 540-552.
SrBOS	Shibuya M, Sagara A, Saitoh A, et al. Biosynthesis of baccharis oxide, a triterpene with a 3, 10-oxide bridge in the A-ring[J]. Organic letters, 2008, 10(21): 5071-5074.
TcOSC1, TcOSC2, TcOSC3,TcOSC4	Han J Y, Jo H J, Kwon E K, et al. Cloning and characterization of oxidosqualene cyclases involved in taraxasterol, taraxerol and bauerenol triterpene biosynthesis in taraxacum coreanum[J]. Plant and Cell Physiology, 2019, 60(7): 1595-1603.
TwOSC1, TwOSC2, TwOSC3	Zhou J, Hu T, Gao L, et al. Friedelane‐type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast[J]. New Phytologist, 2019, 223(2): 722-735.
WsBAS1	Dhar N, Rana S, Razdan S, et al. Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal[J]. Journal of Biological Chemistry, 2014, 289(24): 17249-17267.
WsOSC	Dhar N, Rana S, Razdan S, et al. Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal[J]. Journal of Biological Chemistry, 2014, 289(24): 17249-17267.
WsOSC/BS、WsOSC/LS、WsOSC/CS	Dhar N, Rana S, Razdan S, et al. Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal[J]. Journal of Biological Chemistry, 2014, 289(24): 17249-17267.
MiFRS	Souza-Moreira T M, Navarrete C, Chen X, et al. Screening of 2A peptides for polycistronic gene expression in yeast[J]. FEMS yeast research, 2018, 18(5): foy036.
NsbAS1	Scholz M, Lipinski M, Leupold M, et al. Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa[J]. Phytochemistry, 2009, 70(4): 517-522.
OeOEA	Saimaru H, Orihara Y, Tansakul P, et al. Production of triterpene acids by cell suspension cultures of Olea europaea[J]. Chemical and pharmaceutical bulletin, 2007, 55(5): 784-788.
Osos	Xue Z, Tan Z, Huang A, et al. Identification of key amino acid residues determining product specificity of 2, 3‐oxidosqualene cyclase in Oryza species[J]. New Phytologist, 2018, 218(3): 1076-1088.
OsOSC11	Xue Z, Duan L, Liu D, et al. Divergent evolution of oxidosqualene cyclases in plants[J]. New Phytologist, 2012, 193(4): 1022-1038.
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PdFRS	Han J Y, Ahn C H, Adhikari P B, et al. Functional characterization of an oxidosqualene cyclase (PdFRS) encoding a monofunctional friedelin synthase in Populus davidiana[J]. Planta, 2019, 249(1): 95-111.
PgPNA	Tansakul P, Shibuya M, Kushiro T, et al. Dammarenediol-II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng[J]. FEBS letters, 2006, 580(22): 5143-5149.
PnOSC	Xia P, Zheng Y, Liang Z. Structure and Location Studies on Key Enzymes in Saponins Biosynthesis of Panax notoginseng[J]. International journal of molecular sciences, 2019, 20(24): 6121.
PqDS	Wang L, Zhao S J, Cao H J, et al. The isolation and characterization of dammarenediol synthase gene from Panax quinquefolius and its heterologous co-expression with cytochrome P450 gene PqD12H in yeast[J]. Functional & integrative genomics, 2014, 14(3): 545-557.
ScPEA	Morita M, Shibuya M, Lee M S, et al. Molecular cloning of pea cDNA encoding cycloartenol synthase and its functional expression in yeast[J]. Biological and Pharmaceutical Bulletin, 1997, 20(7): 770-775.
PsPSY	Morita M, Shibuya M, Kushiro T, et al. Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) New α‐amyrin‐producing enzyme is a multifunctional triterpene synthase[J]. European Journal of Biochemistry, 2000, 267(12): 3453-3460.
AltSEQ	Pollier J, Vancaester E, Kuzhiumparambil U, et al. A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis[J]. Nature microbiology, 2019, 4(2): 226-233.
AoSEQ	Tian R, Gu W, Gu Y, et al. Methyl jasmonate promote protostane triterpenes accumulation by up-regulating the expression of squalene epoxidases in Alisma orientale[J]. Scientific reports, 2019, 9(1): 1-13.
AtSEQ	Laranjeira S, Amorim-Silva V, Esteban A, et al. Arabidopsis squalene epoxidase 3 (SQE3) complements SQE1 and is important for embryo development and bulk squalene epoxidase activity[J]. Molecular plant, 2015, 8(7): 1090-1102.
CPSE1-3	Dong L, Pollier J, Bassard J E, et al. Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast[J]. Metabolic engineering, 2018, 49: 1-12.
TwTPS3v2, TwTPS7v2, TwTPS9v2, TwTPS16v2, TwTPS27v2	Su P, Guan H, Zhao Y, et al. Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii[J]. The Plant Journal, 2018, 93(1): 50-66.
ArTPS2	Johnson S R, Bhat W W, Bibik J, et al. A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae)[J]. Journal of Biological Chemistry, 2019, 294(4): 1349-1362.
IeCPS1, IeCPS2, IeCPS3	Du G, Gong H Y, Feng K N, et al. Diterpene synthases facilitating production of the kaurane skeleton of eriocalyxin B in the medicinal plant Isodon eriocalyx[J]. Phytochemistry, 2019, 158: 96-102.
TwTPS2	Hansen N L, Nissen J N, Hamberger B. Two residues determine the product profile of the class II diterpene synthases TPS14 and TPS21 of Tripterygium wilfordii[J]. Phytochemistry, 2017, 138: 52-56.
ArSecTPS	Ye W, He X, Wu H, et al. Identification and characterization of a novel sesquiterpene synthase from Aquilaria sinensis: An important gene for agarwood formation[J]. International journal of biological macromolecules, 2018, 108: 884-892.
AabrBOS1, AabrBOS2, AabrBOS3, bAabrBOS4	Muangphrom P, Misaki M, Suzuki M, et al. Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum[J]. Phytochemistry, 2019, 164: 144-153.
NvTPS	Lancaster J, Lehner B, Khrimian A, et al. An IDS-type sesquiterpene synthase produces the pheromone precursor (Z)-α-bisabolene in Nezara viridula[J]. Journal of chemical ecology, 2019, 45(2): 187-197.
SmTPS1	Luo L Q, Chen Y G, Li D S, et al. Production of the inaccessible sesquiterpene (‐)‐5‐epieremophilene by metabolically engineered Escherichia coli[J]. Chemistry & Biodiversity, 2020.
SiTPS	Karunanithi P S, Berrios D I, Wang S, et al. The foxtail millet (Setaria italica) terpene synthase gene family[J]. The Plant Journal, 2020.
CsTPS	Booth JK, Yuen MMS, Jancsik S, Madilao LL, Page JE, Bohlmann J. Terpene Synthases and Terpene Variation in Cannabis sativa. Plant Physiol. 2020;184(1):130-147.

Pathway (Phenolics)