| Gene | Reference |
|---|---|
| CbTS3 | Ji Z, Fan B, Chen Y, et al. Functional characterization of triterpene synthases in Cibotium barometz. Synth Syst Biotechnol. 2023;8(3):437-444. doi:10.1016/j.synbio.2023.06.005 |
| TgCYP76AE2 | Wong J, d'Espaux L, Dev I, van der Horst C, Keasling J. De novo synthesis of the sedative valerenic acid in Saccharomyces cerevisiae. Metab Eng. 2018;47:94-101. doi:10.1016/j.ymben.2018.03.005 |
| HcOSC6 | Li X, Chen G, Gao QQ, et al. Site-directed mutagenesis identified the key active site residues of 2,3-oxidosqualene cyclase HcOSC6 responsible for cucurbitacins biosynthesis in Hemsleya chinensis. Front Plant Sci. 2023;14:1138893. doi:10.3389/fpls.2023.1138893 |
| AmOSC3 | Chen K, Zhang M, Xu L, et al. Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function. J Adv Res. 2023;43:247-257. doi:10.1016/j.jare.2022.03.014 |
| PcAS | Liu X, Xu Y, Di J, Liu A, Jiang J. The triterpenoid saponin content difference is associated with the two type oxidosqualene cyclase gene copy numbers of Pulsatilla chinensis and Pulsatilla cernua. Front Plant Sci. 2023;14:1144738. doi:10.3389/fpls.2023.1144738 |
| CnVS | Guo X, Sun J, Li D, et al. Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica[J]. Biochemical Engineering Journal, 2018, 137: 125-131 |
| PgPNY | Shibuya M, Zhang H, Endo A, Shishikura K, Kushiro T, Ebizuka Y. Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases. Eur J Biochem. 1999;266(1):302-307. doi:10.1046/j.1432-1327.1999.00875.x |
| TaOSC4 | Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Sci. 2020;292:110382. doi:10.1016/j.plantsci.2019.110382. |
| PvOSC1 | Wang Y, Wang B, Xu F, Ma X. Molecular Cloning and Functional Characterization of Oxidosqualene Cyclases from Panax vietnamensis. Chem Biodivers. 2023;20(2):e202200874. doi:10.1002/cbdv.202200874 |
| TwOSC | Liu Y, Zhou J, Hu T, Lu Y, Gao L, Tu L, Gao J, Huang L, Gao W. Identification and functional characterization of squalene epoxidases and oxidosqualene cyclases from Tripterygium wilfordii. Plant Cell Rep. 2020;39(3):409-418. doi: 10.1007/s00299-019-02499-7. |
| TaOSC1 | Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Sci. 2020;292:110382. doi:10.1016/j.plantsci.2019.110382. |
| PGLSS | Koo H, Lee YS, Nguyen VB, et al. Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis. J Ginseng Res. 2023;47(1):44-53. doi:10.1016/j.jgr.2022.07.001 |
| SINPPS1 | Ignea C, Raadam MH, Motawia MS, Makris AM, Vickers CE, Kampranis SC. Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate. Nat Commun. 2019;10(1):3799. doi:10.1038/s41467-019-11290-x |
| PgPPTS | Dai Z, Wang B, Liu Y, et al. Producing aglycons of ginsenosides in bakers' yeast. Sci Rep. 2014;4:3698. doi:10.1038/srep03698 |
| PGCAS | Koo H, Lee YS, Nguyen VB, et al. Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis. J Ginseng Res. 2023;47(1):44-53. doi:10.1016/j.jgr.2022.07.001 |
| PchAS | Liu X, Xu Y, Di J, Liu A, Jiang J. The triterpenoid saponin content difference is associated with the two type oxidosqualene cyclase gene copy numbers of Pulsatilla chinensis and Pulsatilla cernua. Front Plant Sci. 2023;14:1144738. doi:10.3389/fpls.2023.1144738 |
| VvTS | Zhang C, Li M, Zhao G R, et al. Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory[J]. Microbial cell factories, 2019, 18(1): 160. |
| OpAtCPR1 | Guo X, Sun J, Li D, et al. Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica[J]. Biochemical Engineering Journal, 2018, 137: 125-131 |
| OeCYP716C67 | Alagna F, Reed J, Calderini O, et al. OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea) fruits. New Phytol. 2023;238(5):2047-2063. doi:10.1111/nph.18863 |
| OpCYP706M1 | Guo X, Sun J, Li D, et al. Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica[J]. Biochemical Engineering Journal, 2018, 137: 125-131 |
| TaOSC2 | Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Sci. 2020;292:110382. doi:10.1016/j.plantsci.2019.110382. |
| PvOSC3 | Wang Y, Wang B, Xu F, Ma X. Molecular Cloning and Functional Characterization of Oxidosqualene Cyclases from Panax vietnamensis. Chem Biodivers. 2023;20(2):e202200874. doi:10.1002/cbdv.202200874 |
| AaCYP71AV1 | Wong J, d'Espaux L, Dev I, van der Horst C, Keasling J. De novo synthesis of the sedative valerenic acid in Saccharomyces cerevisiae. Metab Eng. 2018;47:94-101. doi:10.1016/j.ymben.2018.03.005 |
| PvOSC4 | Wang Y, Wang B, Xu F, Ma X. Molecular Cloning and Functional Characterization of Oxidosqualene Cyclases from Panax vietnamensis. Chem Biodivers. 2023;20(2):e202200874. doi:10.1002/cbdv.202200874 |
| PgSQE | Wu Y, Xu S, Gao X, et al. Enhanced protopanaxadiol production from xylose by engineered Yarrowia lipolytica[J]. Microbial cell factories, 2019, 18(1): 83 |
| PgPPDS | Dai Z, Wang B, Liu Y, et al. Producing aglycons of ginsenosides in bakers' yeast. Sci Rep. 2014;4:3698. doi:10.1038/srep03698 |
| AoCAS | Zhang F, Wang Y, Yue J, et al. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Sci Adv. 2023;9(23):eadh1418. doi:10.1126/sciadv.adh1418 |
| TaOSC3 | Srivastava G, Sandeep, Garg A, Misra RC, Chanotiya CS, Ghosh S. Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway. Plant Sci. 2020;292:110382. doi:10.1016/j.plantsci.2019.110382. |
| PGLUS | Koo H, Lee YS, Nguyen VB, et al. Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis. J Ginseng Res. 2023;47(1):44-53. doi:10.1016/j.jgr.2022.07.001 |
| PgDDS | Wu Y, Xu S, Gao X, et al. Enhanced protopanaxadiol production from xylose by engineered Yarrowia lipolytica[J]. Microbial cell factories, 2019, 18(1): 83 |
| CbTS2 | Ji Z, Fan B, Chen Y, et al. Functional characterization of triterpene synthases in Cibotium barometz. Synth Syst Biotechnol. 2023;8(3):437-444. doi:10.1016/j.synbio.2023.06.005 |
| OeBAS | Alagna F, Reed J, Calderini O, et al. OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea) fruits. New Phytol. 2023;238(5):2047-2063. doi:10.1111/nph.18863 |
| TwSQE | Liu Y, Zhou J, Hu T, Lu Y, Gao L, Tu L, Gao J, Huang L, Gao W. Identification and functional characterization of squalene epoxidases and oxidosqualene cyclases from Tripterygium wilfordii. Plant Cell Rep. 2020;39(3):409-418. doi: 10.1007/s00299-019-02499-7. |
| CbTS1 | Ji Z, Fan B, Chen Y, et al. Functional characterization of triterpene synthases in Cibotium barometz. Synth Syst Biotechnol. 2023;8(3):437-444. doi:10.1016/j.synbio.2023.06.005 |
| PGβAS | Koo H, Lee YS, Nguyen VB, et al. Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis. J Ginseng Res. 2023;47(1):44-53. doi:10.1016/j.jgr.2022.07.001 |
/