Alkaloids

Compound	MF	MW	Plant	Family	Medicinal Plant	Category	Pathway link	Reference
(+/-)-Isocorypalmine	C₂₀H₂₃NO₄	341.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/10220	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01243
(R)-N-Methylcoclaurine	C₁₈H₂₁NO₃	299.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Dextromethorphan	https://pubchem.ncbi.nlm.nih.gov/compound/440595	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
(R,S)6-O-Methylnorlaudanosoline	C₁₇H₁₉NO₄	301.34	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/182440	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01243
(R,S)-Methylnorlaudanosoline	C₁₇H₁₉NO₃	285.34	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01241
(R,S)-Norlaudanine	C₁₆H₁₇NO₄	287.31	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240
(R,S)-Norlaudanosoline	C₁₆H₁₇NO₄	287.31	Glaucium flavum	Ranunculaceae Juss.	Yes	Nicotine	https://pubchem.ncbi.nlm.nih.gov/compound/18519	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240
(R,S)-Nororientaline	C₁₈H₂₁NO₄	315.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01242
(R,S)-Norreticuline	C₁₈H₂₁NO₄	315.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/443766	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01243
(R,S)-Scoulerine	C₁₉H₂₁NO₄	327.37	Glaucium flavum	Ranunculaceae Juss.	Yes	Berberine	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01242
(R,S)-Tetrahydrocolumbamine	C₂₀H₂₃NO₄	341.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Berberine	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01243
(R,S)-Tetrahydropalmatinine	C₂₁H₂₅NO₄	355.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240
(S)-1-Hydroxy-N-methylcanadine	C₂₁H₂₄NO₅+	370.4	Papaver somniferum	Papaveraceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/129011756	Dang TT,Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. J Biol Chem. 2014;289 (4):2013-26. doi:10.1074/jbc.M113.505099
(S)-3-hydroxy-methylcoclaurine	C₁₈H₂₁NO₄	315.4	Coptis japonica	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	Inui T,Kawano N,Shitan N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35 (5):650-9. doi:10.1248/bpb.35.652
(S)-3-hydroxy-N-methycoclaurine	C₁₈H₂₁NO₄	315.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-4Methyl-Coclaurine	C₁₈H₂₁NO₃	299.4	Corydalis yanhusuo	Papaveraceae Juss.	Yes	Dextromethorphan	--	Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152
(S)-canadine	C₂₀H₂₁NO₄	339.42	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/21171	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
(S)-cheilanthifoline	C₉H₁₉NO₄	325.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/440582	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
(S)-coclaurine	C₁₇H₁₉NO₃	285.34	Coptis chinensis	Ranunculaceae Juss.	Yes	Dextromethorphan	https://pubchem.ncbi.nlm.nih.gov/compound/160487	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-isococlaurine	C₁₇H₂₀NO₃+	286.34	Coptis chinensis	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/138319297	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-Laudanine	C₂₀H₂₅NO₄	343.4	Glaucium flavum	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/821396	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01242
(S)-N-Methylcanadine	C₂₁H₂₄NO₄+	354.4	Papaver somniferum	Papaveraceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/439844	Dang TT,Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. J Biol Chem. 2Dang TT,Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. J Biol Chem. 2014;289 (4):2013-26. doi:10.1074/jbc.M113.505099014;289 (4):2013-26. doi:10.1074/jbc.M113.505101
(S)-norcoclaurine	C₁₆H₁₇NO₃	271.31	Coptis chinensis	Ranunculaceae Juss.	Yes	Dextromethorphan	https://pubchem.ncbi.nlm.nih.gov/compound/440927	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-reticuline	C₁₉H₂₃NO₄	329.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/439653	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-scoulerine	C₁₉H₂₁NO₄	327.37	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/439654	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
(S)-stylopine	C₁₉H₁₇NO₄	323.3	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/440583	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
(S)-tetrahydrocolumbamine	C₂₀H₂₃NO₄	341.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/440229	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
22(r),26-Dihydroxycholesterol	C₂₇H₄₆O₃	418.7	Veratrum californicum	Melanthiaceae	Yes	Solanine	https://pubchem.ncbi.nlm.nih.gov/compound/122706556	Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871
22(R)-Hydroxycholesterol	C₂₇H₄₆O₂	402.653	Veratrum californicum	Melanthiaceae	Yes	Solanine	https://pubchem.ncbi.nlm.nih.gov/compound/167685	Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871
22-Hydroxy-26-aminocholesterol	--	57222.0	Veratrum californicum	Melanthiaceae	Yes	Solanine	--	Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871
22-Hydroxycholesterol-26-al	--	53962.0	Veratrum californicum	Melanthiaceae	Yes	Solanine	--	Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871
4-O-Methyllarmepavine	C₉H₁₃NO₃	183.2	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	--	Menéndez-Perdomo IM,Facchini PJ. Isolation and characterization of two O -methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ( Nelumbo nucifera ). J Biol Chem. 2020;295 (6):1598-1612. doi:10.1074/jbc.RA119.011548
6-hydroxy-allocryptopine	C₂₁H₂₃NO₆	385.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Atropine	https://pubchem.ncbi.nlm.nih.gov/compound/90659124	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
6-hydroxy-protopine	C₈H₁₃NO₂	155.19	Coptis chinensis	Ranunculaceae Juss.	Yes	Atropine	--	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
7-Deoxyloganic	C₁₆H₂₄O₉	360.36	Capsicum annuum	Solanaceae Juss.	Yes	Atropine	https://pubchem.ncbi.nlm.nih.gov/compound/443322	Yang Y,Li W,Pang J, et al. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chem Biol. 2019;14 (6):1091-1096. doi:10.1021/acschembio.8b01124
Allocryptopine	C₂₁H₂₃NO₅	369.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Atropine	https://pubchem.ncbi.nlm.nih.gov/compound/98570	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
Armepavine	C₁₉H₂₃NO₃	313.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/442169	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
Cholesterol	C₂₇H₄₆O	386.6535	Veratrum californicum	Melanthiaceae	Yes	Solanine	https://pubchem.ncbi.nlm.nih.gov/compound/5997	Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871
Coclaurine	C₁₇H₁₉NO₃	285.34	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Dextromethorphan	--	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
Columbamine	C₂₀H₂₀NO₄+	338.4	Coptis japonica	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/72310	Inui T,Kawano N,Shitan N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35 (5):650-9. doi:10.1248/bpb.35.650
Dihydroberbine	C₂₀H₁₉NO₄	337.4	Coptis chinensis	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/10217	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
D-Tetrahydropalmatine	C₂₁H₂₅NO₄	355.4	Berberis barandana	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/969488	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240
Higenamine	C₁₆H₁₇NO₃	271.31	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Dextromethorphan	https://pubchem.ncbi.nlm.nih.gov/compound/114840	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
isococlaurine	C₁₇H₂₀NO₃+	286.34	Coptis chinensis	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	--	He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732
Jatrorrhizine	C₂₀H₂₀NO₄+	338.4	Corydalis yanhusuo	Papaveraceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/72323	Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152
L-(-)-N-norarmepavine	C₁₈H₂₁NO₃	299.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/6999736	Menéndez-Perdomo IM,Facchini PJ. Isolation and characterization of two O -methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ( Nelumbo nucifera ). J Biol Chem. 2020;295 (6):1598-1612. doi:10.1074/jbc.RA119.011548
Laudanine	C₂₀H₂₅NO₄	343.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/92732	Menéndez-Perdomo IM,Facchini PJ. Isolation and characterization of two O -methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ( Nelumbo nucifera ). J Biol Chem. 2020;295 (6):1598-1612. doi:10.1074/jbc.RA119.011547
Loganin	C₁₇H₂₆O₁₀	390.3823	Capsicum annuum	Solanaceae Juss.	Yes	Terpenoid Alkaloid	https://pubchem.ncbi.nlm.nih.gov/compound/87691	Yang Y,Li W,Pang J, et al. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chem Biol. 2019;14 (6):1091-1096. doi:10.1021/acschembio.8b01124
N-Methylcoclaurine	C₁₈H₂₁NO₃	299.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Dextromethorphan	--	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
Norarmepavine	C₁₈H₂₁NO₃	299.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	--	Menéndez-Perdomo IM,Facchini PJ. Isolation and characterization of two O -methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ( Nelumbo nucifera ). J Biol Chem. 2020;295 (6):1598-1612. doi:10.1074/jbc.RA119.011548
Norcoclaurine	C₁₆H₁₇NO₃	271.31	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Dextromethorphan	--	Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0
Palmatine	C₂₁H₂₂NO₄+	352.4	Coptis japonica	Ranunculaceae Juss.	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/19009	Inui T,Kawano N,Shitan N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35 (5):650-9. doi:10.1248/bpb.35.651
Pronuclferine	C₁₉H₂₁NO₃	311.4	Nelumbo nucifera	Nelumbonaceae A. Rich.	Yes	Isoquinoline Derivatives	--	Menéndez-Perdomo IM,Facchini PJ. Isolation and characterization of two O -methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in sacred lotus ( Nelumbo nucifera ). J Biol Chem. 2020;295 (6):1598-1612. doi:10.1074/jbc.RA119.011547
Protopine	C₂₀H₁₉O₅N	353.37	Coptis chinensis	Ranunculaceae Juss.	Yes	Atropine	https://pubchem.ncbi.nlm.nih.gov/compound/4970	Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0
Scoulerine	C₁₉H₂₁NO₄	327.37	Glaucium flavum	Ranunculaceae Juss.	Yes	Berberine	https://pubchem.ncbi.nlm.nih.gov/compound/22955	Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01242
Secologanin	C₁₇H₂₄O₁₀	388.369	Capsicum annuum	Solanaceae Juss.	Yes	Terpenoid Alkaloid	https://pubchem.ncbi.nlm.nih.gov/compound/161276	Yang Y,Li W,Pang J, et al. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chem Biol. 2019;14 (6):1091-1096. doi:10.1021/acschembio.8b01124
Tropinone	C₈H₁₃NO	139.19	Atropa belladonna	Solanaceae Juss.	Yes	Atropine	https://pubchem.ncbi.nlm.nih.gov/compound/79038	MA,Jones AD,D'Auria JC, et al. Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization. Nat Commun. 2018;9 (1):5281. doi:10.1038/s41467-018-07671-3
Tyrosine	C₉H₁₁NO₃	181.189	Beta vulgaris	Chenopodiaceae	Yes	Isoquinoline Derivatives	https://pubchem.ncbi.nlm.nih.gov/compound/tyrosine	Grewal PS,Modavi C,Russ ZN, et al. Bioproduction of a betalain color palette in Saccharomyces cerevisiae. Metab Eng. 2018;45:180-188.

Compound (Alkaloids)