| Gene | Reference |
|---|---|
| BvCYP76AD1 | Grewal PS,Modavi C,Russ ZN, et al. Bioproduction of a betalain color palette in Saccharomyces cerevisiae. Metab Eng. 2018;45:180-188. doi:10.1016/j.ymben.2017.12.008 |
| AmCYP719A13 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
| CyOMT5 | Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152 |
| CyOMT3 | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| EcCYP719A3 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
| Nu7OMT | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| EcCYP82N2v2 | Takemura T,Ikezawa N,Iwasa K, et al. Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells. Phytochemistry. 2013;91:100-8. doi:10.1016/j.phytochem.2012.02.013 |
| EcCYP719A2 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
| Cj4'OMT | Inui T,Kawano N,Shitan N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35 (5):650-9. doi:10.1248/bpb.35.650 |
| CyOMT2 | Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152 |
| VcCYP90B27 | Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871 |
| CyOMT6 | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| Gf3'OMT | Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240 |
| VcCYP90G1 | Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871 |
| CyOMT7 | Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152 |
| GfSOMT | He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732 |
| GfN7OMT | Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240 |
| Nu6OMT | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| CaCYP72A610 | Yang Y,Li W,Pang J, et al. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chem Biol. 2019;14 (6):1091-1096. doi:10.1021/acschembio.8b01124 |
| Gf4' OMT | Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240 |
| VcCYP94N1 | Augustin MM,Ruzicka DR,Shukla AK, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015;82 (6):991-1003. doi:10.1111/tpj.12871 |
| Cj6OMT | Inui T,Kawano N,Shitan N, et al. Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants. Biol Pharm Bull. 2012;35 (5):650-9. doi:10.1248/bpb.35.650 |
| NuCYP80 | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| CjCYP719A19 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
| CyOMT4 | Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152 |
| CoOMT | He SM,Liang YL,Cong K, et al. Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species. Front Plant Sci. 2018;9:731. doi:10.3389/fpls.2018.00732 |
| AmCYP719A14 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
| CyOMT1 | Bu J,Zhang X,Li Q, et al. Catalytic promiscuity of O -methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022;9:uhac152. doi:10.1093/hr/uhac152 |
| CaCYP72A565 | Yang Y,Li W,Pang J, et al. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS Chem Biol. 2019;14 (6):1091-1096. doi:10.1021/acschembio.8b01124 |
| Nu4' OMT | Menéndez-Perdomo IM,Facchini PJ. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera). Sci Rep. 2023;13 (1):2955. doi:10.1038/s41598-023-29415-0 |
| AbCYP82M3 | MA,Jones AD,D'Auria JC, et al. Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization. Nat Commun. 2018;9 (1):5281. doi:10.1038/s41467-018-07671-3 |
| PsCYP82Y1 | Dang TT,Facchini PJ. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy. J Biol Chem. 2014;289 (4):2013-26. doi:10.1074/jbc.M113.505099 |
| Gf6OMT | Chang L,Hagel JM,Facchini PJ. Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum. Plant Physiol. 2015;169 (2):1127-40. doi:10.1104/pp.15.01240 |
| EcCYP719A5 | Liu Y,Wang B,Shu S, et al. Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids. Nat Commun. 2021;12 (1):3276. doi:10.1038/s41467-021-23611-0 |
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