Alkaloids

Name	Plant	Family	Medicinal Plant	Compound	Category	Function	Reference
BIS1	Catharanthus roseus	Apocynaceae Juss.	Yes	Monoterpene indole alkaloid	Alkaloids	Activator	Van Moerkercke A,Steensma P,Schweizer F, et al. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Proc Natl Acad Sci U S A. 2015;112 (26):8130-5. doi:10.1073/pnas.1504951112
CaLMF	Camptotheca acuminata	Nyssaceae	Yes	Camptothecin	Alkaloids	Repressor	Chang C,Liu Z,Wang Y, et al. A bZIP transcription factor, CaLMF, mediated light-regulated camptothecin biosynthesis in Camptotheca acuminata. Tree Physiol. 2019;39 (3):372-380. doi:10.1093/treephys/tpy106
CjbHLH1	Coptis japonica	Ranunculaceae	Yes	Quinoline alkaloids	Alkaloids	Activator	Yamada Y,Motomura Y,Sato F. CjbHLH1 homologs regulate sanguinarine biosynthesis in Eschscholzia californica cells. Plant Cell Physiol. 2015;56 (5):1019-30. doi:10.1093/pcp/pcv027
CjWRKY1	California poppy	Papaveraceae Juss.	Yes	Benzylisoquinoline alkaloid	Alkaloids	Activator	Yamada Y,Shimada T,Motomura Y, et al. Modulation of benzylisoquinoline alkaloid biosynthesis by heterologous expression of CjWRKY1 in Eschscholzia californica cells. PLoS One. 2017;12 (10):e0186953. doi:10.1371/journal.pone.0186953
CrBPF1	Catharanthus roseus	Apocynaceae Juss.	Yes	Terpenoid indole alkaloid	Alkaloids	Repressor	Li CY,Leopold AL,Sander GW, et al. CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes. Front Plant Sci. 2015;6:818. doi:10.3389/fpls.2015.00818
CrERF5	Catharanthus roseu	Apocynaceae Juss.	Yes	Anhydrovinblastine	Alkaloids	Activator	Pan Q,Wang C,Xiong Z, et al. CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus. Front Plant Sci. 2019;10:931. doi:10.3389/fpls.2019.00931
CrGBF1	Catharanthus roseus	Apocynaceae Juss.	Yes	Indolylalkylamine alkaloid	Alkaloids	Repressor	Sui X,Singh SK,Patra B, et al. Cross-family transcription factor interaction between MYC2 and GBFs modulates terpenoid indole alkaloid biosynthesis. J Exp Bot. 2018;69 (18):4267-4281. doi:10.1093/jxb/ery229
CrGBF2	Catharanthus roseus	Apocynaceae Juss.	Yes	Indolylalkylamine alkaloid	Alkaloids	Repressor	Sui X,Singh SK,Patra B, et al. Cross-family transcription factor interaction between MYC2 and GBFs modulates terpenoid indole alkaloid biosynthesis. J Exp Bot. 2018;69 (18):4267-4281. doi:10.1093/jxb/ery229
CrMYC1	Catharanthus roseus	Apocynaceae Juss.	Yes	Strictosidine	Alkaloids	Activator	Chatel G,Montiel G,Pré M, et al. CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter. J Exp Bot. 2003;54 (392):2587-8. doi:10.1093/jxb/erg275
CrMYC2	Catharanthus roseus	Apocynaceae Juss.	Yes	Terpenoid indole alkaloids	Alkaloids	Activator	Zhang H,Hedhili S,Montiel G, et al. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. Plant J. 2011;67 (1):61-71. doi:10.1111/j.1365-313X.2011.04575.x
CrWRKY1	Catharanthus roseus	Apocynaceae Juss.	Yes	Vinblastine	Alkaloids	Activator	Suttipanta N,Pattanaik S,Kulshrestha M, et al. The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol. 2011;157 (4):2081-93. doi:10.1104/pp.111.181834
OpWRKY6	Ophiorrhiza pumila	Rubiaceae Juss.	Yes	Pentacyclic quinoline alkaloid	Alkaloids	Repressor	Wang C,Hao X,Wang Y, et al. Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila. Hortic Res. 2022;9:uhac099. doi:10.1093/hr/uhac099
TcJAMYC	Taxus cuspidata	Taxaceae Gray	Yes	Taxol	Alkaloids	Activator	Lenka SK,Nims NE,Vongpaseuth K, et al. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcJAMYC1	Taxus cuspidata	Taxaceae Gray	Yes	Taxol	Alkaloids	Repressor	Lenka SK,Nims NE,Vongpaseuth K, et al. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcJAMYC2	Taxus cuspidata	Taxaceae Gray	Yes	Taxol	Alkaloids	Repressor	Lenka SK,Nims NE,Vongpaseuth K, et al. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcJAMYC4	Taxus cuspidata	Taxaceae Gray	Yes	Taxol	Alkaloids	Repressor	Lenka SK,Nims NE,Vongpaseuth K, et al. Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4. Front Plant Sci. 2015;6:115. doi:10.3389/fpls.2015.00115
TcMYB29a	Taxus chinensis	Taxaceae Gray	Yes	Paclitaxel	Alkaloids	Activator	Cao X,Xu L,Li L, et al. TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis. Front Plant Sci. 2022;13:804593. doi:10.3389/fpls.2022.804593
TcWRKY47	Taxus chinensis	Taxaceae Gray	Yes	Taxol	Alkaloids	Activator	Zhang M,Chen Y,Nie L, et al. Transcriptome-wide identification and screening of WRKY factors involved in the regulation of taxol biosynthesis in Taxus chinensis. Sci Rep. 2018;8 (1):5197. doi:10.1038/s41598-018-23558-1
TcWRKY8	Taxus chinensis	Taxaceae Gray	Yes	Taxol	Alkaloids	Activator	Zhang M,Chen Y,Nie L, et al. Transcriptome-wide identification and screening of WRKY factors involved in the regulation of taxol biosynthesis in Taxus chinensis. Sci Rep. 2018;8 (1):5197. doi:10.1038/s41598-018-23558-1
TmMYB3	Taxus media	Taxaceae Gray	Yes	Paclitaxel	Alkaloids	Activator	Yu C,Luo X,Zhang C, et al. Tissue-specific study across the stem of Taxus media identifies a phloem-specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis. Plant J. 2020;103 (1):95-110. doi:10.1111/tpj.14710
TmMYB39	Taxus media	Taxaceae Gray	Yes	Paclitaxel	Alkaloids	Activator	Yu C,Huang J,Wu Q, et al. Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol in Taxus media. Hortic Res. 2022;9:uhac062. doi:10.1093/hr/uhac062
TwTGA1	Tripterygium wilfordii	Celastraceae R. Br.	Yes	Serpentine, Catharanthine	Alkaloids	Activator	Huo Y,Zhang B,Chen L, et al. Isolation and Functional Characterization of the Promoters of Miltiradiene Synthase Genes, TwTPS27a and TwTPS27b , and Interaction Analysis with the Transcription Factor TwTGA1 from Tripterygium wilfordii. Plants (Basel). 2021;10 (2):null. doi:10.3390/plants10020418
TwTGA1	Tripterygium wilfordii	Celastraceae R. Br.	Yes	Vincaleukoblastine	Alkaloids	Repressor	Han J,Liu HT,Wang SC, et al. A class I TGA transcription factor from Tripterygium wilfordii Hook.f. modulates the biosynthesis of secondary metabolites in both native and heterologous hosts. Plant Sci. 2020;290:110293. doi:10.1016/j.plantsci.2019.110293

Transcription factor (Alkaloids)